Staff Scientist, Research (DNA methylation)

San Carlos, CA

Natera is seeking a Staff Scientist to join our Epigenomics Research Team. The primary focus of this role is to independently lead the research and development of novel, methylation-based next-generation sequencing (NGS) technologies. In this role, you will lead projects from ideation to prototype, specifically designing and optimizing high-complexity NGS methods to advance our oncology diagnostic portfolio. Success in this role requires a deep technical foundation in DNA methylation and epigenomics plus a proven track record of industrial R&D leadership.

Primary Responsibilities:

  • Lead and manage the development of innovative NGS-based diagnostic assays from feasibility through optimization.

  • Define project goals and plans with input from stakeholders and manage multiple project streams in parallel.

  • Independently design and execute complex laboratory experiments; analyze and interpret results to guide research direction.

  • Coordinate cross-functional efforts to meet milestones and collaborate closely with bioinformatics, statistics, and data science teams to ensure robust experimental design and data analysis.

  • Mentor and guide junior scientists while promoting scientific rigor and best practices.

  • Author high-quality protocols, technical reports, and study documentation.

  • Communicate progress regularly to stakeholders, including departmental meetings and senior leadership.

  • Contribute to risk management, strategy development, and continuous improvement of scientific workflows.

Qualifications:

  • Ph.D. in molecular biology, genomics, or a closely related field.

  • Minimum 8 years of relevant industry experience, or 2+ years postdoctoral research with 6+ years in industry.

  • Proven experience in designing and advancing NGS-based diagnostics, preferably in the field of oncology.

Required Expertise:

  • Deep technical foundation in molecular biology or chemistry.

  • Extensive hands-on experience with NGS-based methylation detection and epigenomic workflows.

  • Demonstrated ability to independently design and execute complex experiments (solid DOE skills).

  • Creativity and ingenuity in solving high-ambiguity technical challenges.

  • Experience leading research projects in an industrial setting.

Preferred Skills:

  • Experience with cfDNA or liquid biopsy assay development.

  • Deep mechanistic knowledge of NGS library preparation chemistry.

  • Familiarity with translating early-stage research assays toward regulated product environments.

  • Proficiency in statistical analysis tools such as Excel, JMP, R, or Python; familiarity with bioinformatics workflows is a plus.

Compensation & Total Rewards 

This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of  hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including:

  • Annual performance incentive bonus

  • Long-term equity awards

  • Comprehensive health benefits (medical, dental, vision)

  • 401(k) with company match

  • Generous paid time off and company holidays

  • Additional wellness and work-life benefits

Compensation Range

$157,300 - $196,600 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents. 

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

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