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Contract Research Associate/Senior Research Associate – T Cell Engineering and Gene Editing

South San Francisco

Company
Addition Therapeutics is at the forefront of biotechnology innovation, advancing transformative therapies utilizing its proprietary PRINT™ (Precise RNA-mediated Insertion of Transgenes) platform. PRINT™ redefines genetic medicine by enabling development of RNA-only therapeutics capable of inserting any genetic element into specific safe harbor sites within the genome. Operating from state-of-the-art labs in South San Francisco, our team of experienced scientists and drug developers is leading scientific breakthroughs while cultivating a vibrant, dynamic culture committed to profoundly impacting patient lives.

Job description

Addition Therapeutics is seeking a researcher with experience in T cell engineering and gene editing, either in industry or an academic setting. This individual would have experience in both primary lymphocyte culture and assays required to characterize edited T cells. This scientist may also have opportunities to work on projects outside of T cells.

About the Role
The day-to-day responsibilities of this role will include:

  • Execution of experiments involving lymphocyte engineering, gene editing, immunology, synthetic biology, molecular biology, and cell biology.
  • Collaborating on team projects.
  • Communicating, documenting, and presenting work.

Qualifications 

Required:

  • Bachelors Degree in Molecular and Cell Biology, Bioengineering, Immunology, or related fields with 1+ years experience engineering T cells in industry or academia
  • Experience in primary human T cell culture and T cell engineering
  • Experience in RNA synthesis and purification by in vitro transcription
  • Experience in non-viral gene delivery
  • Experience in multi-color flow cytometry, DNA and RNA readout methods (ddPCR, RT-PCR, etc), and culture of cell lines
  • Organized, motivated, and disciplined when it comes to hands-on work in the lab
  • Excellent oral and written communication skills
  • Thrives in a fast-moving, results-oriented startup environment
  • Flexible, cooperative, can-do attitude

Preferred

  • 3+ years experience engineering T cells in industry or academia
  • T cell functional assays (e.g. cytotoxicity, exhaustion, activation)
  • RNA delivery and expression of transgenes
  • Understanding and execution of in vitro and in vivo CAR T mouse efficacy and safety studies

Compensation
The expected hourly rate for this contractor position is $55.00/hour. Actual pay will be determined based on experience, qualifications, business needs, internal equity, and alignment with market data.

We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

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