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Director, Laboratory and Facilities Operations

South San Francisco

Company 

Addition Therapeutics is at the forefront of biotechnology innovation, advancing transformative therapies utilizing its proprietary PRINT™ (Precise RNA-mediated Insertion of Transgenes) platform. PRINT™ redefines genetic medicine by enabling development of RNA-only therapeutics capable of inserting any genetic element into specific safe harbor sites within the genome. Operating from state-of-the-art labs in South San Francisco, our team of experienced scientists and drug developers is leading scientific breakthroughs while cultivating a vibrant, dynamic culture committed to profoundly impacting patient lives.

Job description

We are seeking a dynamic and experienced Director of Laboratory and Facilities Operations to lead the strategy, infrastructure, and day-to-day management of our laboratory and office environments. This individual will be responsible for creating and sustaining a high-performing, safe, and compliant workplace that enables cutting-edge scientific work. The role combines hands-on operational leadership with strategic planning and cross-functional collaboration across R&D, EHS, Procurement, and Facilities.

This role reports to the Head of Operations and will be based onsite.

Responsibilities

  • Strategic Leadership & Infrastructure

    • Lead planning, buildout, and optimization of laboratory and facility operations, including lab expansions, infrastructure upgrades, and capital equipment planning.
    • Establish scalable lab operations frameworks across departments, aligning long-term strategy with daily execution.
    • Develop and manage annual operational budgets for lab and facility services, including forecasting for capital expenditures, maintenance, and lab services.

    Safety & Compliance

    • Serve as the company’s Biosafety officer and primary point of contact for all safety programs across office, lab, and vivarium spaces.
    • Own environmental, health, and safety (EHS) programs and documentation in partnership with internal stakeholders and external consultants.
    • Oversee safety training, onboarding, and compliance audits; lead lab safety committee and coordinate inspections by regulatory agencies (e.g., OSHA, county, state).
    • Maintain all permits and ensure compliance with federal, state, and local safety regulations.
    • Develop and continuously improve incident response protocols, risk assessments, and emergency coverage plans (including after-hours alarms).

    Operational Excellence

    • Lead all facets of daily lab operations, including equipment maintenance (preventive and reactive), calibration, inventory management, procurement, waste management, and lab sustainability initiatives.
    • Lead continuous improvement and standardization of operational practices across multiple lab environments.
    • Develop and maintain inventory systems for consumables, reagents, lab gases, and shared equipment.
    • Oversee lab-wide vendor and service provider relationships; negotiate contracts, manage service levels, and ensure cost-effectiveness.

    Cross-Functional Collaboration

    • Lead organizational communication between lab users, scientific leadership, operations, and corporate functions (e.g., People and Culture, Finance, IT, Legal), for lab and facilities matters.
    • Partner with teams across Research to resolve infrastructure and logistical bottlenecks.
    • Collaborate with People and Culture and onboarding teams to ensure a seamless experience for new hires accessing lab systems and safety training.

Qualifications

  • Bachelor’s degree in a scientific, engineering, or facilities-related discipline required; advanced degree preferred.
  • 10+ years of experience in laboratory/facilities operations in biotech or pharmaceutical environments, with 3+ years in a people or functional leadership role.
  • Deep working knowledge of lab safety regulations and compliance requirements; experience acting as a biosafety officer and leading safety committees.
  • Proven track record overseeing lab buildouts, equipment procurement, lab inspections, and vendor management.
  • Experience working with multiple environments (TC, BSL 2, vivarium) is highly preferred.
  • Strong communication, leadership, and change management skills.
  • This position requires occasional availability outside of normal working hours for emergency response support.

Compensation 

The expected annual salary range for this full-time position is $181,000-$226,200, plus eligibility for bonus, benefits, and equity incentives. Actual pay will be determined based on experience, qualifications, business needs, internal equity, and alignment with market data.

We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

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