In Vivo Operations Lead – Sr. Scientist II – Associate Director

Company:

Addition Therapeutics is at the forefront of biotechnology innovation, advancing transformative therapies utilizing its proprietary PRINT™ (Precise RNA-mediated Insertion of Transgenes) platform. PRINT™ redefines genetic medicine by enabling development of RNA-only therapeutics capable of inserting any genetic element into specific safe harbor sites within the genome. Operating from state-of-the-art labs in South San Francisco, our team of experienced scientists and drug developers is leading scientific breakthroughs while cultivating a vibrant, dynamic culture committed to profoundly impacting patient lives.

Job description:

Addition Therapeutics is seeking a highly skilled and motivated Senior Scientist II / Associate Director to join our dynamic Preclinical Translation Team, focused on advancing our novel PRINT™ platform to the clinic.  The successful candidate will oversee the design, execution, and management of in vivo studies to support platform development and program advancement. This individual will direct and manage internal and external In Vivo Operations with a key focus on design and oversight of rodent and NHP studies at CROs. The ideal candidate will combine technical expertise, operational excellence, and strong leadership to ensure high-quality, reproducible, and compliant in vivo data generation.  They will be a highly collaborative and resourceful scientist with superior communication skills who can work on multiple projects in a fast-paced, matrixed setting.  This role has vast learning opportunities in the field of permanent gene insertion into the genome and presents a unique opportunity to explore the multifaceted applications of PRINT™, paving the way for novel therapeutic avenues/novel therapeutic programs and potential partnerships that could redefine the landscape of genetic medicine.

Key Responsibilities:

• Design and manage execution of in vivo experiments to support target validation, platform development, and therapeutic programs.
• Manage external studies with CROs, including vendor selection, protocol design, study oversight, data review, analysis, interpretation, and presentation to a wide audience.
• Contribute to the design and oversight of NHP studies in collaboration with CROs and internal stakeholders.
• Support design and execution of internal studies, including hands-on procedures such as dosing (IV, IP, SC), blood sampling, necropsy, and tissue collection.
• Ensure compliance with IACUC and animal welfare regulations; draft and amend animal protocols as needed.
• Maintain detailed and organized study records; contribute to study reports and presentations.
• Collaborate closely with appropriate functional teams (research platform, program, bioanalytical, CMC and formulation) to align in vivo strategy and timelines with program objectives and deliverables.
• Provide mentorship, training, and operational guidance to team members as appropriate.
• Oversee histology sample management and contribute to building out in-house capabilities for IHC, ISH / RNAscope and digital pathology workflows.

Qualifications

• M.S. or Ph.D. in Biology, Pharmacology, or related field with 8+ years of relevant industry experience
• Title (Sr. Scientist II to Associate Director) commensurate with experience.
• Strong track record of designing and executing in vivo studies including proficiency in analyzing and interpreting in vivo datasets and generating high-quality reports for internal and external stakeholders.
• Extensive experience managing CROs, including rodent and NHP studies.
• Proven hands-on expertise running in vivo studies in rodent models, including dosing, bleeds, necropsy, and tissue harvests.
• Excellent organizational skills and meticulous attention to detail.
• Outstanding communication skills and ability to work collaboratively across teams.
• Nimble and adaptable in a fast-paced biotech environment.
• Experience drafting and managing IACUC protocols required.
• Preferred: Experience in liver, cardiometabolic, or oncology disease models.
• Strong plus: Hands-on experience with histology workflows including handling, processing, and staining tissue samples for immunohistochemistry, RNAscope, etc. Experience building and running a histology core is highly desirable.
• Team player who fosters a culture of collaboration, accountability, and scientific excellence, and who thrives in a fast-moving, results-oriented startup environment.
• A self-motivated, driven individual with a passion to learn and can-do attitude.

Compensation

The expected annual salary range for this full-time position is $150,000-$210,000, plus eligibility for bonus, benefits, and equity incentives. Actual pay will be determined based on experience, qualifications, business needs, internal equity, and alignment with market data.

We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.