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Scientist, Analytical Development & Quality Control

South San Francisco

Scientist – Analytical Development & Quality Control
South San Francisco, CA | May 2026

Addition Therapeutics leads in biotechnology innovation, advancing transformative therapies through our proprietary PRINT™ platform (Precise RNA-mediated Insertion of Transgenes). PRINT™ redefines genetic medicine by enabling RNA-only therapeutics that insert genetic elements into safe harbor sites within the genome. From our advanced labs in South San Francisco, we drive scientific breakthroughs and foster a collaborative, mission-driven culture dedicated to improving patient lives.

Position Overview

We are looking for a motivated Scientist with expertise in RNA analytical development and quality control. This role focuses on developing, optimizing, and validating analytical methods while supporting QC testing of RNA drug substances and final formulations, offering strong growth opportunities in a fast-paced, cross-functional environment.

Key Responsibilities

Analytical Development

  • Independently develop, optimize, and validate analytical methods for characterizing and quantifying plasmids, IVT impurities, RNA drug substances, lipids, and small molecules.
  • Utilize techniques including CGE, LC-UV/MS, LC-CAD, qPCR, and ELISA.
  • Troubleshoot analytical methods and instrumentation issues.

Quality Control

  • Conduct and interpret QC testing to support Process Development and Formulation teams by assessing materials for in vitro and in vivo studies.

Data Analysis & Reporting

  • Analyze and interpret experimental data; effectively communicate findings to cross-functional teams.
  • Contribute to troubleshooting and continuous improvement of analytical methods and workflows.

Documentation

  • Maintain accurate and detailed laboratory records.
  • Author and review SOPs, analytical methods, and qualification/validation reports to facilitate QC transfer.

Cross-Functional Collaboration

  • Collaborate with Discovery, Process Development, and formulation teams to support research and development efforts.

Qualifications

  • Proven experience in developing and validating quantitative analytical methods for RNA and small molecules.
  • Extensive experience with analytical techniques such as Capillary Gel Electrophoresis (CGE), qPCR, HPLC (CAD/UV), and Mass Spectrometry preferred.
  • Additional experience with Nanopore and ELISA techniques is a plus.
  • Strong analytical thinking and problem-solving skills.
  • Excellent communication and technical writing abilities.
  • Ability to excel in a fast-paced startup environment.
  • Self-motivated, adaptable, and eager to learn.

Education & Experience

  • Ph.D. in Analytical Chemistry, Biochemistry, or related field with 1–3 years of industry experience.
  • Master’s with 6-8 years. OR Bachelor’s with 9 -10 years

Compensation

The expected hourly rate for this position is $111,000-$140,000. Exact compensation may vary based on skills and experience.

We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

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