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Research Associate Sr. RA – Pharmaceutical Science (Contractor)

South San Francisco

Addition Therapeutics is at the forefront of biotechnology innovation, advancing transformative therapies utilizing its proprietary PRINT™ (Precise RNA-mediated Insertion of Transgenes) platform. PRINT™ redefines genetic medicine by enabling the development of RNA-only therapeutics capable of inserting any genetic element into specific safe harbor sites within the genome. Operating from state-of-the-art labs in South San Francisco, our team of experienced scientists and drug developers is leading scientific breakthroughs while cultivating a vibrant, dynamic culture committed to profoundly impacting patient lives.

About the Role: Addition Therapeutics is seeking a highly motivated scientist, contractor with experience in RNA or related modality manufacturing and QC testing. This contract position is at the Senior Research Associate level. The ideal candidate will contribute to RNA production and characterization of the production process.  The successful candidate is detail-oriented and who is excited by new challenges and cross-functional teamwork. This position has vast learning opportunities in the field of permanent gene insertion into the genome.

The day-to-day responsibilities of this role will include, but are not limited to:

  • Producing RNA in small to mid-scale reactions
  • Preparing reagents, sub-aliquoting, maintaining reagent logs, and inventory
  • Contribute to creating and documenting protocols and techniques.
  • Collaborate with the analytical team to determine purity and levels of undesired impurities in DNA and RNA products.
  • Support QC assays, including purity, safety, and content
  • Collect and prepare accurate and timely data summaries and review written reports.
  • Stay current with relevant scientific literature and implement new techniques or practices to improve quality and efficiency

 

Requirements:

Highly desired:

  • Experience with manufacturing DNA, RNA, or gene therapy-related modalities (GMP or non-GMP)
  • Good documentation practice with experience in an electronic notebook
  • Thrives in a fast-moving, results-oriented startup environment
  • Self-motivated, passionate, and eager to continuously learn
  • Experience with external vendor communications.

Significant Plus:

  • Experience with tangential flow filtration, AKTA purification, and bioreactors
  • Experience with QC assays, including Fragment Analyzer, LAL Endotoxin, and Fluorescence-based quantitation
  • Familiarity and hands-on experience in molecular biology and cell biology
  • Familiarity with JMP statistical software

Education: Bachelor’s or master’s degree in chemistry, biochemistry, or related field with 2-4 years of experience 

Compensation

The expected hourly rate for this position is $55.00-$60.00 / hour. Exact compensation may vary based on skills and experience.

We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

 

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