Scientist I, Tx Radiochemistry CMC

Your Impact

Alpha-9 Oncology is seeking a highly motivated Scientist, Tx CMC Radiochemistry with a strong background in radiolabeling process development, drug product formulation, and analytical method development to join our innovative CMC team. In this role, you will collaborate closely with cross-functional teams, including Process Chemistry, Analytical Development, External Manufacturing, and Translational Research, to drive the development and delivery of targeted peptide- and small molecule-based radiopharmaceuticals for both diagnostic and therapeutic use. You'll have the chance to make a real impact on our mission while enjoying a dynamic work environment that fosters learning and career progression.

Reporting to the Associate Director, CMC Operations, you will play a key role in shaping our radiochemistry platform and supporting the advancement of novel radiolabeled compounds into preclinical and clinical development. This includes contributing to technology transfer efforts with CDMO partners and helping to establish new lab capabilities. This role is based in our Vancouver office.

How You'll Contribute

• Conduct radiochemistry experiments leading to robust radiolabeling processes and clinical formulations that meet target product and stability profiles for therapeutic applications.
• Design and conduct experiments, critically evaluate data, draw appropriate conclusions and develop follow-up plan of action to determine critical process parameters and establish process ranges.
• Develop technology transfer package for transfer of radiolabeling and analytical methods to third party CRO and CDMO partners and serve as a representative on a project team in the capacity of process chemist expert.
• Collaborate with multidisciplinary teams to define development project goals and timelines.
• Support CDMO investigations by troubleshooting and identifying unusual results and designing experiments that establish root cause and/or enhance knowledge of the product being developed.
• Author, revise and review technical documents including SOPs, development reports, test methods, experimental and qualification protocols, batch records, specifications and regulatory documents. Provide project data and progress status updates to internal cross-functional project team
• Recommend and implement continuous improvements with respect to safe handling of radioactive substances in the laboratory environment according to applicable Nuclear Safety Regulations (Canadian Nuclear Safety Commission).
• Adhere and follow radiation safety regulations as set in the policies and conduct area radiation surveys, contamination control, radioactive waste management.
• Ensures compliance with Health and Safety, policies, procedures and regulations applicable to the work.
• Conduct work according to best practices and where appropriate, regulatory guidance, international pharmacopeias, ICH, established protocols and standard operating procedures.

The Skills you Bring

• Ph.D. in Radiochemistry, Chemistry, Analytical Chemistry, Nuclear Engineering, or a related field with a minimum of 1–2 years of relevant industry or postdoctoral experience; or M.Sc. with at least 6 years of experience in radiopharmaceutical process development, formulation, production, or technology transfer in academic and/or commercial settings.
• Hands on experience in radiolabeling with radioisotopes used in therapeutic applications (e.g., Lu-177 and Ac-225).
• Ability to plan and execute complex scientific projects. Strong analytical and trouble shooting skills.
• Ability to handle more than one project at a time, multitasking, effective communicator and collaborative with different teams.
• Functional knowledge of radiopharmaceutical process/formulation chemistry, standard concepts of radiochemistry, best practices, regulatory requirements for development of radiopharmaceuticals in various jurisdiction.
  
  

What's in it for you:

At Alpha-9 Oncology, we offer a competitive and comprehensive benefits package designed to support all employees. Our benefits include a competitive salary, bonus, equity, 20 vacation days, 5 sick days, a technology allowance, and commuter reimbursement. We also provide generous retirement savings plans with employer matching, extended health benefits, and paid holidays, tailored to local standards in each region. While specific offerings may vary by location, our commitment to fostering a supportive and rewarding work environment is consistent across the company.

Company Summary

Alpha-9 Oncology is a clinical-stage biotechnology company pioneering radiopharmaceutical innovation for solid tumors. Our proprietary scaffolds, composed of optimized binders, linkers, chelators, and radioisotopes, enable targeted radiation delivery to cancer cells, minimizing harm to surrounding healthy tissue. Focusing on innovative targeting moieties, we develop molecules tailored for precise tumor targeting.

Our comprehensive platform integrates imaging and therapeutic studies to ensure effective radiation delivery and improved patient outcomes. With a robust pipeline entering clinical trials and strong support from leading healthcare investors, Alpha-9 is positioned for rapid growth and advancement in cancer therapy.

More about Alpha-9 Oncology

Alpha-9 Oncology is committed to fostering a diverse and inclusive workplace and is proud to be an Equal Opportunity Employer. We provide employment opportunities to all qualified applicants without regard to race, ethnicity, religion, age, sex, gender identity or expression, sexual orientation, disability, marital status, family status, national origin, or any other characteristic protected by applicable federal, provincial, or local laws where we operate.

We are dedicated to providing reasonable accommodations to qualified applicants and employees to ensure that everyone can perform their essential job functions in an inclusive environment. For inquiries regarding accommodations in the hiring process or for current employees, please contact a member from our Talent Acquisition team.