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Vice President, Commercial Operations

Cambridge, MA

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve.

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.

THE OPPORTUNITY

As a key member of the Commercial Leadership Team, the Vice President, Commercial Operations will establish and lead the commercial operations function, ensuring the infrastructure, processes, and strategies necessary for successful product commercialization. This role oversees sales operations, forecasting and analytics, incentive compensation, market research, data management, CRM systems, field effectiveness, and commercial training. The leader in this role will act as a strategic partner across multiple functions, including Sales, Marketing, Market Access, Patient Services, Medical Affairs, Finance, IT, and Compliance, to drive commercial excellence and business growth.

This role offers an opportunity to shape the Commercial Operations function from the ground up, supporting a high-impact product launch and long-term business growth.

We anticipate filling this role in Q3 of 2025.

RESPONSIBILITIES

Commercial Strategy & Leadership

  • Serve as a key member of the Commercial Leadership Team, developing and executing commercial strategy and operational plans.
  • Oversee the design and optimization of commercial operations, including market research, forecasting, data analytics, sales reporting, and performance tracking.
  • Develop a best-in-class commercial infrastructure that aligns with business objectives and supports pre-launch and post-launch activities.
  • Lead Quarterly Business Reviews (QBR) and Board of Directors (BoD) process preparation, including performance reporting and insights.
  • Partner cross-functionally with Marketing, Sales, Finance, Compliance, Market Access, and Medical Affairs to drive aligned strategic execution.

Sales & Field Operations

  • Design and implement field force structure, including sizing, territory alignment, and resource allocation.
  • Oversee field effectiveness, including CRM system implementation, sales enablement tools, and customer engagement reporting.
  • Develop and manage incentive compensation plans to motivate and retain top sales talent while ensuring compliance.
  • Establish field insights and reporting frameworks, providing timely and data-driven recommendations to sales leadership.
  • Support field training and development programs in collaboration with Sales Training teams.

Market Insights, Analytics & Data Management

  • Lead the development and governance of commercial data strategy, ensuring seamless integration and utilization of sales, claims, specialty pharmacy, and CRM data.
  • Develop competitive intelligence, customer targeting methodologies, and KPIs to assess commercial performance.
  • Design dashboards, analytics tools, and reporting mechanisms that provide actionable insights for leadership decision-making.
  • Partner with IT and external vendors to build and maintain a commercial data environment (CDE) that supports sales forecasting, revenue tracking, and strategic planning.

Operational Excellence & Budget Management

  • Manage commercial operations budgets, ensuring efficient allocation of human and financial resources.
  • Drive process improvements, system enhancements, and operational efficiencies to optimize commercial execution.
  • Oversee congress and event operations, including commercial presence at industry meetings.
  • Ensure compliance with industry regulations and internal policies in all commercial activities.

REQUIRED QUALIFICATIONS

  • Bachelor's degree required; MBA or advanced degree preferred.
  • 12+ years in commercial operations, sales analytics, or related functions within the pharmaceutical, biotechnology, or healthcare industry. Experience in rare diseases, specialty pharma, or product launches strongly preferred.
  • Proven ability to build and lead high-performing teams in a fast-paced, evolving environment.
  • Strong business acumen with the ability to analyze complex data, forecast market trends, and drive strategic decision-making.
  • Demonstrated ability to work effectively across multiple departments, influencing senior leadership and cross-functional teams.
  • Experience with CRM systems, sales analytics, market insights, data governance, and incentive compensation design.
  • Strong written and verbal communication skills, with experience presenting insights to executive leadership and board members.
  • Ability to navigate ambiguity, prioritize initiatives, and implement innovative commercial solutions.

WORK LOCATION AND CONDITIONS

  • At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Delaware, Hawaii and Kansas.
  • While this is a remote role, preference will be given to candidates who reside within New England and can attend meetings at our office in Cambridge, MA on an as-needed basis.
  • You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
  • You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

 

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Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.

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