Back to jobs
New

Vice President, Commercial Operations

Cambridge, MA

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve.

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.

THE OPPORTUNITY

As a key member of the Commercial Leadership Team, the Vice President, Commercial Operations will establish and lead the commercial operations function, ensuring the infrastructure, processes, and strategies necessary for successful product commercialization. This role oversees sales operations, forecasting and analytics, incentive compensation, market research, data management, CRM systems, field effectiveness, and commercial training. The leader in this role will act as a strategic partner across multiple functions, including Sales, Marketing, Market Access, Patient Services, Medical Affairs, Finance, IT, and Compliance, to drive commercial excellence and business growth.

This role offers an opportunity to shape the Commercial Operations function from the ground up, supporting a high-impact product launch and long-term business growth.

We anticipate filling this role in Q3 of 2025.

RESPONSIBILITIES

Commercial Strategy & Leadership

  • Serve as a key member of the Commercial Leadership Team, developing and executing commercial strategy and operational plans.
  • Oversee the design and optimization of commercial operations, including market research, forecasting, data analytics, sales reporting, and performance tracking.
  • Develop a best-in-class commercial infrastructure that aligns with business objectives and supports pre-launch and post-launch activities.
  • Lead Quarterly Business Reviews (QBR) and Board of Directors (BoD) process preparation, including performance reporting and insights.
  • Partner cross-functionally with Marketing, Sales, Finance, Compliance, Market Access, and Medical Affairs to drive aligned strategic execution.

Sales & Field Operations

  • Design and implement field force structure, including sizing, territory alignment, and resource allocation.
  • Oversee field effectiveness, including CRM system implementation, sales enablement tools, and customer engagement reporting.
  • Develop and manage incentive compensation plans to motivate and retain top sales talent while ensuring compliance.
  • Establish field insights and reporting frameworks, providing timely and data-driven recommendations to sales leadership.
  • Support field training and development programs in collaboration with Sales Training teams.

Market Insights, Analytics & Data Management

  • Lead the development and governance of commercial data strategy, ensuring seamless integration and utilization of sales, claims, specialty pharmacy, and CRM data.
  • Develop competitive intelligence, customer targeting methodologies, and KPIs to assess commercial performance.
  • Design dashboards, analytics tools, and reporting mechanisms that provide actionable insights for leadership decision-making.
  • Partner with IT and external vendors to build and maintain a commercial data environment (CDE) that supports sales forecasting, revenue tracking, and strategic planning.

Operational Excellence & Budget Management

  • Manage commercial operations budgets, ensuring efficient allocation of human and financial resources.
  • Drive process improvements, system enhancements, and operational efficiencies to optimize commercial execution.
  • Oversee congress and event operations, including commercial presence at industry meetings.
  • Ensure compliance with industry regulations and internal policies in all commercial activities.

REQUIRED QUALIFICATIONS

  • Bachelor's degree required; MBA or advanced degree preferred.
  • 12+ years in commercial operations, sales analytics, or related functions within the pharmaceutical, biotechnology, or healthcare industry. Experience in rare diseases, specialty pharma, or product launches strongly preferred.
  • Proven ability to build and lead high-performing teams in a fast-paced, evolving environment.
  • Strong business acumen with the ability to analyze complex data, forecast market trends, and drive strategic decision-making.
  • Demonstrated ability to work effectively across multiple departments, influencing senior leadership and cross-functional teams.
  • Experience with CRM systems, sales analytics, market insights, data governance, and incentive compensation design.
  • Strong written and verbal communication skills, with experience presenting insights to executive leadership and board members.
  • Ability to navigate ambiguity, prioritize initiatives, and implement innovative commercial solutions.

WORK LOCATION AND CONDITIONS

  • At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Delaware, Hawaii and Kansas.
  • While this is a remote role, preference will be given to candidates who reside within New England and can attend meetings at our office in Cambridge, MA on an as-needed basis.
  • You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
  • You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

 

To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn.

To return to our website please click here.

Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.

Apply for this job

*

indicates a required field

Resume/CV*

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter

Accepted file types: pdf, doc, docx, txt, rtf


Select...
Select...
Select...
Select...

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Amylyx Pharmaceuticals’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.