Back to jobs

Senior Director, Health Economics and Outcome Research/Real World Evidence

Cambridge, MA

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve.

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.

THE OPPORTUNITY

The Senior Director, Health Economics and Outcomes Research (HEOR)/Real World Evidence (RWE) at Amylyx Pharmaceuticals will report to the SVP of Medical Affairs. This position will be an expert and experienced leader, engaging cross functionally to develop and drive HEOR and evidence generation strategies. The Senior Director will play an integral role in developing and communicating the value proposition for Amylyx’ assets, including our lead program in post-bariatric hypoglycemia (PBH).  This role will drive development of strategies, methods, and tools to ensure successful market access, adoption, and long-term impact in support of Amylyx’ mission to find solutions for patients with high unmet needs.

RESPONSIBILITIES

Strategic Leadership

  • Build and lead the HEOR function including the development of integrated HEOR and evidence generation strategies and tactical plans to support Amylyx’s therapeutic programs
  • Lead evidence gap analyses that will inform the HEOR strategic and tactical plans and lead cross-functional data generation and communication planning efforts to support health economic/value proposition and inform understanding of treatment patterns, disease burden, patient-reported outcomes, and unmet needs

 

Evidence Generation & Study Execution

  • Design and execute projects, such as burden of illness, real-world clinical outcomes, clinical registries, retrospective database analyses, and meta-analyses.
  • Provide scientific support for protocol development, target product profiles, data collection strategies, literature review and evidence synthesis
  • Stakeholder Engagement & Communication
  • Oversee the development of peer-reviewed publications, conference presentations, and internal communication of HEOR findings.
  • Support global market access strategy and plans for Amylyx pipeline products including, identifying opportunities for early scientific advice with key health technology assessment (HTA) agencies, regulatory support and preparing for global HTA models. Incorporate any recommendations into the clinical development program.

Cross-Functional Collaboration

  • Ensure all HEOR tactics are aligned cross-functionally with business strategies and regulatory guidelines.
  • Monitor and interpret U.S. policy changes (e.g., IRA, CMS guidance) and translate implications into actionable HEOR strategies.
  • Collaborate with Market Access and Medical Affairs to develop and maintain evidence packages tailored to U.S. payers, including commercial plans, Medicare, and Medicaid.

Team & Vendor Management

  • Lead vendor selection and manage external research partners to ensure high-quality and timely study delivery.
  • Build and manage a team to support innovative real-world evidence generation and health economics research.
  • Manage HEOR budget planning and resource allocation to ensure efficient execution of strategic priorities

REQUIRED QUALIFICATIONS

  • 10+ years healthcare or pharmaceutical industry experience with minimum 7 in HEOR
  • Master's Degree (MS, MPH, PharmD, PhD) in a relevant discipline (e.g., health economics, medicine, pharmacy, public health, epidemiology) required
  • Demonstrated success in designing and leading real-world research to support US payer value and access.
  • Experience supporting HEOR strategy for product launch, including pre-launch evidence generation and payer engagement, is highly desirable.
  • Deep understanding of U.S. healthcare system dynamics, including payer structures, value-based care, and regulatory trends.
  • Excellent leadership and cross-functional collaboration skills, with the ability to influence and drive strategy across teams and with external partners and vendors
  • Excellent analytical skills, including in-depth knowledge of COAs and pharmacoeconomic modeling and retrospective database analysis methodologies.
  • Experience working with U.S. claims databases, EMRs, and patient registries; proficiency in RWE analytics platforms and methodologies.
  • Knowledge of endocrine and/or obesity space a plus

Ability to travel up to 20%

WORK LOCATION AND CONDITIONS

  • At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska and Hawaii. 
  • You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
  • You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

 

To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn.

To return to our website please click here.

Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Create a Job Alert

Interested in building your career at Amylyx Pharmaceuticals? Get future opportunities sent straight to your email.

Apply for this job

*

indicates a required field

Resume/CV*

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter

Accepted file types: pdf, doc, docx, txt, rtf

Select...
Select...
Select...
Select...

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Amylyx Pharmaceuticals’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.