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Sr. Scientist/Principal Scientist, Toxicology (Small Molecule)

Boston, MA

Salary Band: $160,000-$220,000

Location: Downtown Boston, MA (In-Office Minimum 3 Days/week)

Position Summary

Antares Therapeutics is seeking an enthusiastic and self‑motivated Senior Scientist/Principal Scientist, Toxicology to join the Nonclinical Development group and support nonclinical safety assessment activities from discovery through IND‑enabling stages across the Antares pipeline.

The successful candidate will play a key role in the design, execution, and interpretation of nonclinical safety studies, working both hands‑on in the laboratory and in close collaboration with external CROs. This role requires scientific independence, strong technical expertise in in vitro and in vivo safety assessment, and effective cross‑functional collaboration in a fast‑paced, matrixed environment.

Key Responsibilities

  • Serve as a nonclinical safety representative on cross‑functional Discovery and Development project teams, supporting program progression through IND‑enabling stages.
  • Design, execute, and troubleshoot nonclinical safety studies, including hands‑on assay execution, data generation, and interpretation. Up to 40% of time in the lab. 
  • Support the oversight of GLP and non‑GLP nonclinical safety studies conducted at CROs, including active involvement in troubleshooting assay‑ and study‑related challenges.
  • Work in the laboratory to establish and run in vitro safety assays, with an emphasis on New Approach Methodologies (NAMs).
  • Analyze and interpret study data, contributing to study reports, regulatory documentation, and IND‑supporting materials under guidance.
  • Collaborate closely with Pharmacology, DMPK, and other functional teams to support exploratory and mechanistic safety studies.
  • Identify and communicate potential safety findings and actively contribute to discussions on risk assessment, data interpretation, and next‑step recommendations.
  • Ensure all studies and internal activities are conducted in compliance with regulatory guidelines, GLP principles, and internal standards.

Required Qualifications

  • Ph.D. or M.S. in Toxicology or a related scientific discipline.
  • Minimum 5+ years of industry experience in pharma or biotechnology focused on nonclinical safety assessment.
  • Demonstrated ability to work independently while contributing scientific expertise within cross‑functional teams.
  • Experience supporting nonclinical safety programs from discovery through IND‑enabling stages.
  • Strong problem‑solving skills, attention to detail, and ability to manage multiple priorities in a dynamic environment.

Preferred Expertise

  • Hands‑on experience with one or more of the following:
    • In vitro 3D models
    • In vitro safety screening platforms
  • Familiarity with NAM‑based approaches for safety assessment.
  • Experience interacting with and overseeing work performed at external CROs.

Personal Attributes

  • Proactive, collaborative, and scientifically curious.
  • Positive, flexible attitude with the ability to thrive in a matrixed, fast‑paced biotech environment.
  • Strong written and verbal communication skills.

The anticipated annual salary range for this position is $160,000-$220,000 annually. The actual salary offered will be based on a number of factors, including but not limited to the qualifications of the applicant, years of relevant experience, level of education attained, certifications or other professional licenses held, and if applicable, the location in which the applicant lives and/or from which they will be performing the job.

 

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