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Senior Director, Clinical Scientist -Neuroscience

Remote, Hybrid, New Haven - CT

Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins.

In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs currently enrolling:  ARV-102 for the treatment of patients with neurodegenerative disorders,ARV-393 for the treatment of patients with relapsed/refractory non-Hodgkin Lymphoma and potentially other lymphomas, and ARV-806, a KRAS G12D PROTAC for the treatment patients with solid tumors with KRAS G12D mutations.  

On August 8th 2025, the U.S. Food and Drug Administration (FDA)  accepted the New Drug Application (NDA) for vepdegestrant- an investigational, orally bioavailable PROTAC estrogen receptor degrader- for its use as a monotherapy in the treatment of adults with estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2-), ESR1-mutated advanced or metastatic breast cancer previously treated with endocrine-based therapy. In September 2025, Arvinas and Pfizer announced their plan to jointly select a third party for the out-licensing and commercialization of vepdegestrant.

 

In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC androgen receptor protein degrader ARV-766 for the treatment of prostate cancer. The transaction closed in May 2024.

#TeamArvinas is made up of passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say.

 

For more information, please visit www.arvinas.com. 

Position Summary 

The Clinical Scientist is responsible for providing scientific support for all Global Clinical Development activities. This role includes assembling, evaluating, and presenting scientific and medical data, writing or providing content to clinical documents (clinical study protocols and protocol synopses, papers, abstracts, posters, etc.), monitoring the competitive landscape and reviewing and summarizing relevant literature to provide strategic input. This position requires a strong scientific background; in addition, the candidate must be able to clearly communicate concepts and information both in writing and via formal presentations to scientific and medical experts both internal and external to the company. The Clinical Scientist needs to possess the ability to think creatively, function independently, deliver on timelines, have good strategic insights and have a detailed knowledge of the activities and procedures involved in clinical drug development.

The Clinical Scientist will collaborate with Clinical Operations, Translational Sciences, Clinical Pharmacology, Regulatory, Research and other functions within Arvinas, as well as key partners external to the company. Working closely with colleagues in Clinical Development, the Clinical Scientist will have a substantial role in the development of the clinical documents, the review of scientific and clinical data and the communication of data to the scientific and medical communities.

This position reports to the Head of Clinical Sciences and can be hybrid at our headquarters in New Haven, CT, or remote from a location within the U.S.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

 

Clinical Document Development

  • Lead the development of clinical study protocol synopses and full protocols, including engage with subject matter experts (internal and external) on study design elements and endpoints
  • Contribute to the clinical portion of investigator brochures review for consistency and applicability
    • Contribute in the writing and review of clinical study reports (CSRs), data safety update reports (DSURs), annual reports and regulatory briefing books
    • Manage development of internal and external presentations/publications (manuscripts, posters, etc.) of clinical study data
    • Participate in publication planning
    • Contribute to writing of departmental working processes (SOPs, templates, etc)

Clinical Study Planning

  • Assist clinical research physician in developing clinical development plans
  • Contribute to the development of data collection tools, statistical analysis plans (SAPs), case report forms (CRFs)
  • Collaborate with cross-functional study team to ensure timely study start-up including CRO selection, Data monitoring committee/Independent Radiology Reviewer activities, Central Lab on-boarding etc

 

Study Data Review and Analysis

  • Lead development of Medical Monitor Plans
  • Perform ongoing clinical data review and critical analysis of study data including partnering with clinical research physician
  • Partner with Clinical Operations, Translational Medicine, Pharmacovigilance, Data management and other functional team members at assure quality and timely study conduct and monitoring
  • Provide support as needed for clinical and scientific issues that may arise during study execution
  • Work closely with biostatisticians and programmers to plan analyses of clinical data
  • Support data summaries for leadership, advisory board meetings, etc

 

Review of Scientific Literature

  • Perform literature searches and critically review and summarize the relevant scientific, drug development and medical literature to support document development, such as the investigator brochure, protocol design, clinical study report, competitive assessments, etc.
  • Provide scientific/medical supportive materials to in-house staff and external consultants in the indications being studied
  • Identify and review literature that addresses specific topics of interest relevant to Arvinas drug candidates

Qualifications

Required:

Advanced, doctoral level degree preferred such as PhD, MD, MSc/MPH, PharmD, BS/ MS with relevant professional experience may be considered.

    • 10+ years of experience within a pharmaceutical company environment required. 
    • Neurodegenerative/neuromuscular disease experience /educational background required
    • Advanced knowledge of GCP/ICH, drug development process, study design, statistics, clinical operations in the neurodegenerative/neuromuscular disease setting required
    • Excellent project management, communication and organizational skills required with demonstrated success in leading projects and interacting with cross-functional teams
    • Passionate commitment and a strong team player
    • Ability to work independently and reliably deliver objectives of high quality in a timely manner
    • The duties of this role are generally conducted in a home or corporate office environment. Employees must be able, with or without accommodation, to use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

 

Arvinas will not be providing VISA sponsorship for this position now or in the future. You must have the ability to work without a need for current or future VISA sponsorship.

 

INSERT JOB DESCRIPTION HERE

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identify, national origin, disability or protected veteran status. 

 

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