Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins.

In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs currently enrolling:  ARV-102 for the treatment of patients with neurodegenerative disorders,ARV-393 for the treatment of patients with relapsed/refractory non-Hodgkin Lymphoma and potentially other lymphomas, and ARV-806, a KRAS G12D PROTAC for the treatment patients with solid tumors with KRAS G12D mutations.  

On August 8^th 2025, the U.S. Food and Drug Administration (FDA)  accepted the New Drug Application (NDA) for vepdegestrant- an investigational, orally bioavailable PROTAC estrogen receptor degrader- for its use as a monotherapy in the treatment of adults with estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2-), ESR1-mutated advanced or metastatic breast cancer previously treated with endocrine-based therapy. In September 2025, Arvinas and Pfizer announced their plan to jointly select a third party for the out-licensing and commercialization of vepdegestrant.

In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC androgen receptor protein degrader ARV-766 for the treatment of prostate cancer. The transaction closed in May 2024.

#TeamArvinas is made up of passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say.

For more information, please visit www.arvinas.com. 

Position Summary

Arvinas is seeking a highly motivated and experienced Asset Team Leader to lead cross-functional teams that are accountable, in partnership with the functional leaders on the Asset Team, for the strategy and seamless execution of early oncology development programs.

The successful candidate will work to recommend and drive the strategy of early oncology assets and execution against planned timelines. The Asset Team Leader will lead a cross-functional team including clinical research, clinical operations, regulatory affairs, clinical pharmacology, translational/companion diagnostics, CMC, non-clinical, medical affairs and New Product Planning to deliver against the program strategy. The successful candidate will have experience in early phase development of oncology or related programs.

This role will report to the SVP, Asset Strategy and Team Leadership and can be remote, hybrid, or located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

• Lead cross-functional oncology asset teams and act as main point of contact and program representative to executive management
• Negotiate with and influence key internal and external stakeholders
• Drive generation and execution of the program strategy and Integrated Development Plans with a multidisciplinary matrixed team.  Lead alignment on plans with governance and executive management. Create program strategies that maximize the overall long-term
• Work closely to coordinate strategic and operational efforts with key functions, including Clinical Research, Clinical Operations, Regulatory, CMC, New Product Planning and Project Management to ensure strategic alignment and seamless execution to deliver the greatest value to patients, physicians, payors, and Arvinas

• Partnering with Research to move programs out of exploratory research and into development
• Collaborate with functional leads to create and evaluate detailed scenario plans based on the external landscape and business needs

• Create, manage and optimize timelines, financial accountability, and other vital metrics for multiple projects simultaneously and ensure effective coordination of activities and deliverables across all functions
• Work closely with the Project Manager on program progress, cost, resource allocation, timelines, etc. and collaborate with functional team leads to proactively identify risks, resolve issues and optimize performance
• Drive team objective setting, prioritization and performance to ensure adherence to plan and strategy
• Drive proactive risk management, issue identification and resolution, and contingency planning
• Create a positive team environment in order to achieve the highest level of performance by instilling trust and ensuring clear, transparent communications, and building consensus behind the overall goal/vision for the programs
• Represent the programs at governance and decision-making meetings
• Lead and/or support other corporate objectives involving the assets including Board meeting preparation, earnings preparations and corporate presentations
• Lead the External Engagement subteam
• Supervise and mentor junior staff

Qualifications

• Significant drug development leadership experience, with history of effective management of cross functional teams, key external stakeholders and partners, specifically including leadership of early oncology asset teams
• Minimum of 15 years of relevant experience in the pharmaceutical, academic and/or medical research environments
• Proven ability to lead and influence data-driven strategy planning and implementation
• A proactive and strategic thinker, with strong decision-making skills
• Proven ability to function effectively across a matrix organization with multiple stakeholders and constituents, with the ability and strength to focus a team to work towards its goals
• Demonstrated experience in successfully leading teams: running them effectively, efficiently and on target

• Ability to work cooperatively within a cross-functional, partially virtual team setting is critical, as are strong interpersonal communication skills

• Strong leadership and communication skills (including presentation skills) with success in influencing all levels cross-functionally
• Excellent business acumen and judgment with demonstrated ability to align teams to corporate strategy to achieve business and project objectives
• Strong staff management and mentoring experience and skills
• Highly collaborative with outstanding relationship building skills
• Arvinas will not be providing VISA sponsorship for this position now or in the future. You must have the ability to work without the need for current or future VISA sponsorship.
• The duties of this role are generally conducted in combination of company office and home office environments. Employees must be able, with or without accommodation, to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours.

Education

• Ph.D., MD or MBA or advanced degree in biomedical sciences or one of the disciplines related to drug development

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identify, national origin, disability or protected veteran status.