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Research Associate, Cellular Biology

South San Francisco, California, United States

Atomic AI is a well-funded, early-stage biotechnology company revolutionizing drug discovery by integrating artificial intelligence with structural biology. Our proprietary R&D platform, featured on the cover of Science, enables the design of novel therapeutics targeting RNA structure, opening new avenues for treating previously undruggable diseases. We are a highly interdisciplinary team that values collaboration, innovation, and the people who make our mission possible.

About the Role

We are seeking a Research Associate in Cellular Biology to join our drug discovery team and contribute to the development of RNA-targeting technologies. This role involves hands-on wet lab work, focusing on cell-based assay development, cellular engineering, and high-throughput screening to support our preclinical programs.

The ideal candidate will have experience in mammalian cell culture, molecular biology techniques, and cell-based assays. You will work closely with a cross-functional team to advance our RNA targeting technology platform, providing key cellular proof-of-concept data for RNA-targeting therapeutics.

Key Responsibilities

  • Cell-Based Assay Development & Execution:

    • Design and construct expression vectors (plasmids).
    • Engineer transient and stable reporter cell lines for structure-activity relationship (SAR) studies and validation.
    • Perform high-throughput screening and secondary validation using cell-based and biochemical assays.
    • Conduct assays including qPCR, luciferase, fluorescent protein, and Western blotting.
  • Molecular & Cellular Biology Techniques:

    • Validate antibodies for Western blot analysis.
    • Develop and culture CDX (cell-derived xenograft) lines that express target genes at disease-relevant levels.
    • Perform RNA production for sequences >120 nt.
  • Cell Line Development & Maintenance:

    • Culture and maintain mammalian cell lines, including CDX models.
    • Execute transient and stable cell transfections.
    • Optimize and troubleshoot cell-based assays for in-cell proof-of-concept studies.
  • Data Management & Collaboration:

    • Maintain meticulous records of experiments in an ELN (electronic lab notebook).
    • Analyze and present data in team meetings.
    • Collaborate with internal teams and external CROs to advance project milestones.

Qualifications

  • Education & Experience:

    • BS/MS in Biology, Molecular Biology, or a related field with 2-5 years of relevant industry experience.
    • Strong background in cell-based assays, molecular biology, and protein/RNA analysis.
  • Technical Expertise:

    • Hands-on experience with mammalian cell culture, transfections, and reporter assay development.
    • Proficiency in qPCR, Western blotting, luciferase assays, and fluorescence-based assays.
    • Experience with RNA isolation and production (>120 nt).
    • Familiarity with high-throughput screening techniques and liquid handlers is a plus.
  • Soft Skills & Mindset:

    • Detail-oriented with strong organizational and troubleshooting skills.
    • Ability to work both independently and in a team.
    • Excellent scientific record-keeping and data analysis abilities.

Salary range: $85,000 - $95,000/year + equity + benefits

Atomic AI is committed to equal employment opportunity regardless of race, color, ancestry, national origin, religion, sex, age, sexual orientation, gender identity and expression, marital status, disability, or veteran status.

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