Biologist
(ID: 2025-0446)
Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).
Benefits:
- 100% Medical, Dental & Vision Coverage for Employees
- Paid Time Off (Including Holidays)
- Employee Referral Bonus
- 401K Match
- Tuition reimbursement and professional development opportunities
- Flexible Spending Accounts:
- Healthcare (FSA)
- Parking Reimbursement Account (PRK)
- Dependent Care Assistant Program (DCAP)
- Transportation Reimbursement Account (TRN)
Overview
Axle is looking to add a driven, flexible, organized, and meticulous Biologist to our dynamic team. The Contractor(s) shall provide services in support of the overall functions of the Vaccine Research Center (VRC), Vaccine Production Program (VPP).
Technical Requirements:
- Contribute to the generation of stable cell lines for vaccine and therapeutic protein candidates including monoclonal antibodies, recombinant proteins, and virus-like particles.
- Prepare plasmid DNA using standard molecular cloning techniques including PCR, restriction digest, and bacterial culture.
- Independently execute each step of the cell line development process:
- Transfection
- Pool generation
- Single cell cloning
- Clone expansion in static culture plates and shake flasks
- Fed-batch analysis
- Clone stability studies
- Use automated platforms for clone selection and screening.
- Participate in cell line development platform design, optimization, and cycle-time reduction studies including methods for clone selection, expansion, ranking, and characterization.
- Perform small-scale process development studies using various culture vessels including tissue culture plates, shake flasks, and small-scale bioreactors.
- Generate stable pools and perform transient protein production for supply of reagent-grade material
- Independently complete experiments and analyze data with minimal supervision.
- Provide laboratory support for medium preparation and ordering of supplies.
- Write and review technical reports documenting process development studies and stable cell line generation work.
- Work with other team members to generate experimental plans for process development studies.
- Write and review standard operating procedures for cell line development processes and instrumentation.
- Maintain complete documentation records, including a detailed and up-to-date laboratory notebook, to support regulatory filings.
- Coordinate cell line development projects in collaboration with the project lead and Federal Task Leader:
- Plan experiments to fit within required timelines
- Communicate any issues or delays promptly and help to identify solutions
- Maintain cell line development master sheet file with all critical information and data
- Regularly communicate progress to project lead and present work to cell line development team.
- Participate in project meetings.
- Contribute results and studies for publication in peer-reviewed journals.
- Maintain broad knowledge of state-of-the-art principles.
Specific Qualifications:
- B.S. in Biological Sciences is required.
- Minimum of 4 years of relevant work experience is required.
- Hands-on experience with aseptic technique and mammalian cell culture.
- Experience in preparing technical reports, standard operating procedures, and data presentations.
- Ability to work independently to execute defined experiments and troubleshoot issues as needed to meet project timelines.
- Ability to effectively communicate plans, results, challenges, and ideas to other team members in oral and written forms.
- Familiarity with computer software for word processing and data analysis.
- Experience in monoclonal antibody and/or vaccine production.
The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.
Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com
Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.
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