Clinical Scientist - Oncology

About BridgeBio Oncology Therapeutics

BridgeBio Oncology Therapeutics (“BBOT”) is a clinical-stage company. Our team of researchers are working to develop novel therapeutics to address dire unmet needs in RAS-driven tumors. Led by top scientists with extensive track records in drug development, like Frank McCormick and Eli Wallace, our team utilizes structure-based drug discovery techniques to target some of oncology’s most challenging and validated molecular targets, including KRAS and PI3Kα. We are focused and committed to patients, scientific excellence, and operational agility, and we understand that every minute counts in our efforts to develop new therapies to transform the lives of people living with cancer. Our main oncology laboratory is located in South San Francisco, though our research collaborators span the country and globe.

Who You Are

Clinical Scientist with proven track record of accomplishments within clinical development in the industry setting. Reporting to the Senior Medical Director, Clinical Development, this role will have primary responsibility for all medical aspects pertaining to assigned clinical studies in treating multiple solid tumors. Responsibilities include executing global Phase 1 to Phase 3 studies, with an emphasis on first-in-human (FIH) studies. This role works collaboratively with multi-disciplinary teams responsible for designing, implementing, monitoring, analyzing, and reporting studies conducted within the BridgeBio Oncology Therapeutics portfolio to ensure the program meets the needs of patients and the business. This role will influence both internal and external audiences in a high-impact, prominent role as it actively contributes to the dynamic and innovative culture within the company. 

Responsibilities

• Support Medical Monitor or serve as clinical lead of a phase 1a/1b study and future late-stage studies, including contributing to/overseeing study start-up, enrollment, study medical monitoring, data cleaning, and CSR writing
• Partner with investigators and CROs to design and implement clinical studies, respectively
• Write protocols, investigator brochures, and clinical study reports, and review clinical trial documents
• Conduct investigator meetings and safety review committee meetings and lead site initiation visits with clinical trial investigators
• Execute and deploy drug development strategic plans, develop contingency plans, provide technical and strategic advice, and meet milestones and budgets
• Translate findings from research and non-clinical studies into clinical development opportunities ·
• Interact with clinical investigators and thought leaders
• Conduct clinical trials using ethical guidelines relevant to the pharmaceutical industry, and ensure compliance with these external guidelines

Education, Experience & Skills Requirements

• PhD or Pharm D, with at least 3 years of oncology clinical development experience
• Experience in all aspects of protocol conduct, both early and late phases, including protocol writing, start-up, study execution, analysis, and reporting
• Deep commitment to understanding needs and improving the lives of patients, and a passion for developing novel therapeutics
• Demonstrated ability to collaborate successfully with multiple functions in a team environment, including clinical operations, regulatory, and clinical pharmacology
• Demonstrated record of accomplishment in a compressed time frame; capable of prioritizing tasks and delivering on deadlines with high-performance standards and attention to detail
• Motivated to work in a fast-paced, high accountability, small company environment; a "can do" and collegial professional who leads through influence and interpersonal skills
• Intellectually curious with the courage to challenge and seek new ways to improve work
• Strong written and oral communication skills, including presentation skills
• Ability to analyze and interpret data and develop written reports and presentations of those data
• Solid critical, strategic, and analytical thinking skills
• Travel (US and ex-US) required, to attend scientific conferences and study sites as needed.