Senior Research Associate, Discovery Biology

About BridgeBio Oncology Therapeutics

BridgeBio Oncology Therapeutics (BBOT) is a clinical-stage biopharmaceutical company advancing a next generation pipeline of novel small molecule therapeutics targeting RAS and PI3K malignancies. Initially formed as a subsidiary of BridgeBio Services, BBOT completed a $200M private financing with external investors in 2024 with the goal of improving outcomes for patients with cancers driven by the two most prevalent oncogenes in human tumors. 

For more information visit bridgebiooncology.com.

Who You Are

This is an exciting opportunity for a highly motivated Senior Research Associate with a strong background in cancer biology to join BBOT’s search for innovative cancer therapeutics. We are looking for a talented and enthusiastic individual who thrives in a collaborative, fast-paced, and growing environment to join our team as a laboratory-based leader. As a key member of the Oncology Therapeutics Group, you will:

• Play a critical intellectual and technical role in the discovery and development of novel small molecule cancer therapeutics.
• Independently design, conduct, and analyze experiments to advance our understanding of cancer biology and propel drug discovery programs across our oncology pipeline.
• Execute pharmacology experiments (biochemical and cell-based assays) to assess the inhibition or activation of cell signaling in the oncology setting, including in response to small molecule inhibitors.
• Conduct compound screening (including medium- and high-throughput studies) to identify leads and potential combination therapies.
• Develop novel tools (such as genetically engineered cell lines) and assays as needed to support the group’s discovery mission.
• Communicate your findings across seniority levels within and beyond BBOT.
• Collaborate closely with colleagues across scientific functions and departments, providing key scientific expertise and guidance in an interdisciplinary environment.
• Provide scientific and technical leadership to junior team members.
• Keep complete and timely records in electronic lab notebooks.

Education, Experience & Skills Requirements

• A./B.S + 5 years’ experience or M.A./M.S. + 3 years’ experience in a relevant discipline (e.g. Cancer Biology, Genetics, Molecular Biology).
• Relevant prior research or industry experience in a cell/molecular biology laboratory, ideally within an oncology setting.
• Broad knowledge of cancer biology and independence in critical thinking and scientific achievement.
• Experience with a broad range of cellular and biochemical techniques, including mammalian tumor cell culture and engineering, CRISPR, RNAi, immuno-blotting, NGS, IF/IHC, and FACS.
• Research experience in oncology drug discovery project teams, cancer cell-based assay design, and assay development is advantageous.
• Strong problem-solving skills and a commitment to continuous learning and development.
• Ability to excel in a highly-collaborative and innovative environment.