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Director, CMC Portfolio Management & Operations

Boston, Massachusetts, United States; Durham, North Carolina, United States

About Beeline Medicines:

Beeline Medicines is a clinical‑stage biotechnology company focused on developing and delivering category-leading precision therapies to transform the lives of people living with autoimmune and inflammatory diseases. With a portfolio of potential best-in-class and first-in-disease therapeutic candidates that directly target key pathways governing dysregulated immunological and inflammatory responses, the Company is developing medicines that have the opportunity to provide durable, life-changing impact. Led by an established executive team and backed by world-class life science investors, each day Beeline Medicines is determined to bring the scientific rigor and operational excellence to get to what matters for patients – realizing a world where people with immune-mediated diseases can live life fully.

Job Summary:

The Director, CMC Portfolio Management & Operations is a critical enterprise-level role serving as the operational backbone of the Chief Technical Operations Officer's organization. This individual is responsible for establishing and running the CMC program management framework, driving cross-functional operational cadence, and ensuring that the company's CMC portfolio is planned, tracked, and delivered with rigor and transparency. Sitting at the intersection of science, strategy, and operations, this leader brings structured program management discipline to a fast-moving, pre-commercial biotech environment — enabling the CMC leadership team to make high-quality decisions efficiently, allocate resources strategically, and keep pipeline programs on track. This role does not manage a deep scientific function but rather elevates the effectiveness of the entire CMC organization through operational excellence, portfolio visibility, and organizational rhythm.


Work Arrangement & Location: 

Hybrid - This position follows a hybrid work schedule, requiring a minimum of two (2) days on-site per week — currently designated as Tuesday and Wednesday. Additional on-site days may be required based on business needs, team priorities, or leadership direction.


Essential Duties and Responsibilities:

  • Design and own the CMC portfolio management framework, including integrated development timelines, cross-program milestone tracking, risk registers, and stage-gate decision processes across all active programs.
  • Serve as the primary program management partner to the Chief Technical Operations Officer, preparing executive-level portfolio reviews, board materials, and CMC readout packages for senior leadership.
  • Establish and lead the operational cadence of the CMC organization — including leadership team meetings, cross-functional program reviews, quarterly planning cycles, and annual operating plan development.
  • Own the CMC resource planning and capacity management process, working with CMC functional leaders to model headcount needs, CDMO bandwidth, and external partner capacity against portfolio demands.
  • Build and maintain a centralized CMC portfolio dashboard, ensuring real-time visibility into program status, key milestones, risks, issues, and dependencies across the pipeline.
  • Lead CMC-wide process improvement initiatives, identifying operational bottlenecks, standardizing project management practices, and implementing tools and systems that scale with organizational growth.
  • Partner with Finance to develop and track the annual CMC budget, provide variance reporting, and ensure accurate forecasting of program spend across internal and external activities.
  • Coordinate cross-functional CMC interfaces with Clinical Development, Regulatory Affairs, Quality, Supply Chain, and Program Management to ensure seamless information flow and aligned deliverable timelines.
  • Manage and continuously improve CMC knowledge management systems, ensuring critical documents, decision logs, SOPs, and program records are organized, accessible, and current.
  • Support Business Development, partnership, and due diligence activities from an operational perspective, including the preparation of CMC data rooms, CMC capability summaries, and program timeline materials for external audiences.
  • Perform other duties and responsibilities as assigned


Qualifications:

  • Education: Bachelor's degree required; advanced degree (M.S., Ph.D., or MBA) in a life sciences, or engineering discipline strongly preferred
  • 10+ years of experience in pharmaceutical or biopharmaceutical program/project management, portfolio operations, or CMC operations, with at least
  • 3 years in a cross-functional leadership or senior individual contributor role within matrix CMC organization.
  • Deep understanding of the drug development process, with specific familiarity with CMC development activities across small molecules and/or biologics from IND through NDA/BLA.
  • Experience building and managing integrated CMC development timelines, resource models, and cross-program risk registers in a multi-asset biotech or pharma setting.
  • Proven ability to design and implement operational infrastructure in a pre-commercial or rapidly scaling organization, including meeting cadences, reporting frameworks, and decision-support systems.
  • Experience supporting budget development, financial tracking, and variance analysis for a technical R&D function in collaboration with Finance.
  • Familiarity with CDMO governance, external partner management, and the operational interfaces between internal CMC teams and contract organizations.
  • Demonstrated ability to lead through influence in a matrixed organization, aligning senior scientific and operational stakeholders around shared priorities without direct line authority over all constituents.
  • Strong written and verbal communication skills, with a track record of producing high-quality portfolio reviews, operating plan documents, and cross-functional alignment materials.
  • Skilled facilitator with experience leading executive-level meetings, planning sessions, and cross-functional working groups with clarity, structure, and appropriate follow-through.
  • Collaborative communication style with the ability to build trust and credibility quickly across scientific, operational, regulatory, financial, and business development stakeholders in a matrixed organization.

Salary Range:

The expected annual salary range for this position is listed below. Actual pay will be determined based on experience, qualifications, location, and other job-related factors permitted by law. A discretionary annual bonus and long-term incentive award (e.g., equity) may be available based on individual and Company performance.

Salary Range

$219,000 - $231,000 USD

Benefits:

We offer a comprehensive benefits package including:

  • Medical, Dental & Vision insurance (employee premiums 100% covered by company)
  • 20 accrued days combined time off (PTO/Sick), 12 company holidays, & winter recharge
  • Flexible work arrangements / hybrid schedule
  • Health Savings Account (HSA)

*Benefits are subject to eligibility requirements and plan terms. Additional details provided during the offer process*

Equal Employment Opportunity:

Beeline Medicines is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, disability, age, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Reasonable Accommodation:

If you require a reasonable accommodation to participate in the application or interview process, please contact careers@beelinemedicines.com to request an accommodation. We are committed to providing equal access to all candidates.

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