Senior Scientist

BillionToOne is a next-generation molecular diagnostics company dedicated to developing powerful and accurate diagnostic tests that are accessible to all. Our innovative QCT molecular counting technology significantly enhances the resolution of disease detection using cell-free DNA by over a thousandfold. This groundbreaking technology is integral to our product offerings, including one of our flagship products, Unity Complete™, the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. Leveraging the same molecular counting technology, we've expanded our impact into oncology in 2023 with a pioneering liquid biopsy test, Northstar, that combines treatment selection with monitoring. To date, over 500,000 patients have benefited from our innovative and precise diagnostic tests, and our Annual Recurring Revenue (ARR) has grown from $0 to $125 million in the last ~4 years.

BillionToOne has successfully raised close to $400 million in funding, with a notable $130 million Series D round completed in June 2024, resulting in a company valuation of over $1 billion. This funding has come from prestigious global institutional investors, including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest. BillionToOne has recently been recognized by Forbes as one of America's Best Startup Employers for 2024, highlighting the company's exceptional work environment and commitment to innovation.

Our team has grown significantly and we now proudly employ over 400 highly skilled individuals. Despite substantial growth, we have successfully maintained the unique culture that has defined BillionToOne from inception, continuing to cultivate a team that is not only diverse and passionate but also innovative. Headquartered in Menlo Park, California, with an additional facility in Union City, California, BillionToOne remains at the forefront of significant advances in molecular diagnostics, evidenced by the recent announcement of clinical outcomes data for its Unity Fetal Risk Screen and new advancements in cancer diagnostics. For more detailed information about BillionToOne and its groundbreaking work, please visit our website at www.billiontoone.com.

We are currently seeking a Senior Scientist to further develop our product pipeline. We are looking for a quantitative biologist, biophysicist, or bioengineer who can own the end-to-end R&D process, both able to design complex high-throughput molecular biology experiments & analyze complex, quantitative data that the experiments generate. Our Senior Scientists serve as principal investigators with significant resources and direct reports. They own end-to-end research and product development. This is an extremely impactful position, appropriate for an inspired scientist and extraordinary problem solver. The Senior Scientist position is an onsite position located at our state of the art Menlo Park laboratory and will report directly to the CEO/CTO.

Responsibilities:

• Learn, use and modify our custom R/Python code for experimental design purposes, and complement them with bioinformatic tools as needed.
• Plan and develop the research strategy.
• Design (and be able to perform) experiments to validate diagnostic/screening assays.
• Analyze experiments and troubleshoot them as necessary.
• Read the literature from chemistry and molecular biology to synthetic biology, bioengineering, and statistical learning fields to find creative opportunities for further improvements in our assays.
• Mathematically/computationally model experimental processes to iterate on the research strategy and assay development.

Requirements:

• PhD in biological sciences, bioengineering, biophysics, or related discipline with molecular biology lab experience
• A deep quantitative understanding of and approach to biology
• A strong background in physics, applied mathematics, or mathematical biology (i.e., you intuitively understand concepts such as error propagation, probability distributions, Markov models, Monte Carlo simulations, phase diagrams etc.)
• Ability to analyze data and model biological processes in R or Python
• Knowledge of data structures and algorithms and familiarity with industry tools (Github, command line, AWS)

Nice-to-Haves:

• Next-generation-sequencing experience
• A deep understanding of or experience with nucleic acid chemistry

Benefits And Perks:

• Working with a team of ‘rockstars’ who bring out the best in everyone
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousand patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered at 80%
• Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
• Retirement savings program including a 4% Company match
• Free daily on-site lunches provided from top eateries
• Latest and greatest hardware (laptop, lab equipment, facilities)
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based experience and salary/equity options split that the candidate chooses) (2) generous equity options offering, on top of (3) industry leading company benefits (free healthcare options, 401k match, very generous fully paid paternal leave etc.).

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.