Ready to redefine what's possible in molecular diagnostics?

Join a team of brilliant, passionate innovators who wake up every day determined to transform healthcare. At BillionToOne, we've built something extraordinary—a culture where transparency fuels trust, collaboration drives breakthroughs, and every voice matters in our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we strive to build products that are 10x better than anything that exists today. Our people are our greatest asset: talented scientists, engineers, sales professionals, and visionaries united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion—every innovation you contribute helps remove fear of unknown from some of life's most critical medical moments. If you're driven by purpose, energized by innovation, and ready to help build the future of precision medicine, this is where you belong.

We are seeking a highly skilled and experienced General Ledger Accountant to join our growing team.  This role will be responsible for taking ownership of the month-end close journal entries, accruals, reconciliations, and analyses for various functional areas including but not limited to cash, investments, prepaid expenses, fixed assets, use tax, accounts payable, accrued liabilities, on top of assisting with vendor setup, vendor review, purchase orders as needed. The ideal candidate will be a hands-on and process-improvement-oriented individual that can own and support various areas. Our integrated team believes in collaboration, flexibility, resourcefulness, and attention to detail. This role will continue to take on increasingly complex challenges in a growth environment. This is a hybrid position and will report to the Director of Accounting.

Responsibilities:

• Execute monthly close: journal entries, accruals, reconciliations (cash, investments, prepaid expenses, sales tax, accounts payable accounting).
• Ability to investigate and resolve accounting discrepancies.
• Prepare and analyze account fluxes and supporting documentation.
• Oversee vendor management: process vendor requests, maintain master records, support AP reconciliations, and purchase order procedures.
• Manage Expensify entries and reconciliations, ensuring accurate expense allocation.
• Coordinate daily cash reporting, monitor cash activity, and assist with forecasting and bank account management.
• Collaborate with supply chain and procurement to ensure compliance and workflow efficiency.
• Support external audits: prepare schedules, documentation, and respond to auditor requests.
• Uphold internal controls and influence process improvements.
• Provide active support of projects and system enhancements.

Qualifications:

• Bachelor’s in Accounting, Finance, or Economics (required); CPA/MBA preferred.
• 3–5 years’ combined public and industry accounting experience.
• Proficiency in NetSuite and advanced Excel (formulas, pivot tables, data analysis).
• Solid understanding of GAAP, Sarbanes-Oxley, and internal controls.
• Experience in process optimization, system implementation, and cross-functional collaboration.

Benefits And Perks:

• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
• Supplemental fertility benefits coverage 
• Retirement savings program including a 4% Company match
• Increase paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)
• Free daily on-site lunches provided from top eateries
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, we offer a total compensation package of $144,833 per year, including a base pay range of $104,040 - $124,848 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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About BillionToOne

BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA—a breakthrough that's already transformed the lives of over half a million patients worldwide.

Our Impact: We've pioneered game-changing diagnostic solutions that are redefining industry standards. Unity Complete™ stands as the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. In oncology, our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth: From $0 to $125 million in Annual Recurring Revenue in just four years. We've raised close to $400 million in funding, including a $130 million Series D round in June 2024, achieving a valuation of over $1 billion. This backing comes from world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition: Forbes recently named us one of America's Best Startup Employers for 2025, and we were awarded Great Place to Work certification in 2024—with an incredible 100% of our people reporting they are willing to give extra to get the job done. These honors recognize not just our innovation but the exceptional culture we've cultivated—one that remains authentically collaborative and transparent even as we've scaled.

Our Future: Headquartered in Menlo Park with facilities in Union City, California, we're continuing to push the boundaries of what's possible in molecular diagnostics. Recent clinical outcomes data for Unity Fetal Risk Screen and new advances in cancer diagnostics prove we're just getting started.

At BillionToOne, you'll join a diverse team of passionate innovators who believe that the best science happens when brilliant minds collaborate openly, think boldly, and never lose sight of the patients whose lives depend on our work.

Ready to help us change the world, one diagnosis at a time?

Learn more at www.billiontoone.com