VP Business Operations, Chief of Staff to CEO

BillionToOne is a next-generation molecular diagnostics company dedicated to developing powerful and accurate diagnostic tests that are accessible to all. Our innovative QCT molecular counting technology significantly enhances the resolution of disease detection using cell-free DNA by over a thousandfold. This groundbreaking technology is integral to our product offerings, including one of our flagship products, Unity Complete™, the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. Leveraging the same molecular counting technology, we've expanded our impact into oncology in 2023 with a pioneering liquid biopsy test, Northstar, that combines treatment selection with monitoring. To date, over 500,000 patients have benefited from our innovative and precise diagnostic tests, and our Annual Recurring Revenue (ARR) has grown from $0 to $125 million in the last ~4 years.

BillionToOne has successfully raised close to $400 million in funding, with a notable $130 million Series D round completed in June 2024, resulting in a company valuation of over $1 billion. This funding has come from prestigious global institutional investors, including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest. BillionToOne has recently been recognized by Forbes as one of America's Best Startup Employers for 2024, highlighting the company's exceptional work environment and commitment to innovation.

Our team has grown significantly and we now proudly employ over 400 highly skilled individuals. Despite substantial growth, we have successfully maintained the unique culture that has defined BillionToOne from inception, continuing to cultivate a team that is not only diverse and passionate but also innovative. Headquartered in Menlo Park, California, with an additional facility in Union City, California, BillionToOne remains at the forefront of significant advances in molecular diagnostics, evidenced by the recent announcement of clinical outcomes data for its Unity Fetal Risk Screen and new advancements in cancer diagnostics. For more detailed information about BillionToOne and its groundbreaking work, please visit our website at www.billiontoone.com.

We are looking for a highly impactful VP Business Operations, Chief of Staff to CEO. This is a senior leadership role with a path to C-suite positions. The successful candidate will build and lead their own Business Operations function while serving as a key strategic thought partner and advisor to the CEO. This role will drive the execution of critical projects, ensuring alignment across the organization for company wide OKRs, leading executive leadership meetings. This person will support strategic decision-making in preparation for our IPO as a member of the prestigious IPO team, and in our 20 Mile March towards the S&P 500 post-IPO as a member of the executive leadership team. 

As a true strategic partner to the CEO, you will have complete access to all executive information and decision-making processes, serving as an extension of the CEO's office. This role will drive organizational efficiency, supporting operational excellence, and managing complex, cross-functional initiatives. This high-visibility role will require a strong blend of strategic thinking, operational expertise, and leadership acumen. This person will help our CEO and other members of the executive team to maintain our strong culture and operational excellence, as we scale from 500 to 2000 employees and grow revenues from $200M ARR to $1B+ ARR over the next five years.

The Chief of Staff is an on-site position and reports directly to our CEO.

Responsibilities: 

Strategic Planning & Execution

• Serve as a strategic thought partner to the CEO on critical business decisions, organizational design, and long-term strategy
• Collaborate closely with the CEO and senior leadership to define and implement the company’s strategic roadmaps, with a focus on the execution of high-impact initiatives.
• Build and lead the Business Operations organization, with opportunity to expand scope to additional operational functions over time
• Partner with other executive leadership team members to track progress on quarterly and annual objectives and key results (OKRs), ensuring alignment with overall business goals.
• Provide detailed analysis and insights to support executive decision-making, enabling informed and timely actions.
• Drive organizational transformation initiatives across culture, operations, and strategy

Operational Excellence

• Drive improvements in operational efficiency by identifying and addressing bottlenecks, streamlining processes, and fostering a high-performance work culture.
• Own internal communication strategies to ensure alignment across teams on key priorities and goals.
• Lead the preparation and coordination of important meetings (e.g., Board meetings, Executive Leadership Team meetings), ensuring clarity of purpose, setting agendas, and tracking follow-up actions.
• Foster high-performing company culture and support talent acquisition efforts for senior leadership roles and key hires.

Leadership & Stakeholder Support

• Serve as a strategic advisor to the CEO, offering insights and recommendations on key business decisions.
• Work closely with the CEO’s ensuring that their time is aligned with the company's strategic priorities.
• Help CEO and senior leadership focus on the highest-priority initiatives by managing day-to-day operational needs and addressing ad-hoc challenges that arise.

Requirements:

• 15+ years of experience in strategy, operations, or management consulting, with a proven track record of working with senior leadership teams in high-growth environments
• Proven experience as either VP Level Business Operations leader, General Manager, or Chief of Staff at a high growth innovative company (Tech or Life Science) or a division of a large cap company
• Technical acumen and passion for learning, understanding, and applying technical concepts, such as BillionToOne’s core QCT technology and its differentiation, digital twins for personalized medicine, and agentic AI
• Track record of building and leading high-performing organizations
• Experience managing or influencing a variety of stakeholders within a hypergrowth division/organization (at least 50% YoY revenue growth)
• Deep experience leading company-wide OKR process
• Demonstrated success in working across core business functions
• Strong analytical, communication, and organizational skills, with the ability to synthesize complex information and present it in an easily digestible format
• Ability to work in a fast-paced, dynamic environment, managing ambiguity and driving results with limited resources
• Servant leader mindset with a passion for leading highly collaborative high-performing teams with integrity and discretion
• Experience in the life sciences or diagnostics industries is highly preferred
• Experience in management consulting is preferred
• Experience supporting an IPO is a plus

Education:

• Bachelor’s degree in Business, Life Sciences, Engineering, or a related field. 
• An MBA is preferred

Benefits And Perks:

• Working with a team of ‘rockstars’ who bring out the best in everyone
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousand patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered at 80%
• Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
• Retirement savings program including a 4% Company match
• Free daily on-site lunches provided from top eateries
• Latest and greatest hardware (laptop, lab equipment, facilities)
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

For this position, the base salary is $275,000 per year with an annual bonus at plan of 25% and a total equity package of $1.5M ($375,000/year), for a total compensation package exceeding $700,000 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.