Automation Engineer

Ready to redefine what's possible in molecular diagnostics?

Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.

Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.

If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.

Automation Engineer, BillionToOne, Inc., Menlo Park, CA. Lead the development, optimization, and implementation of automated workflows for genomic DNA extraction, NGS library preparation, and other molecular biology techniques; Design and integrate custom Python-based solutions to enhance liquid handler and LIMS interactions; Manage and improve service tracking systems for CLIA production instruments; Collaborate with R&D and clinical teams to scale up new assays and transfer them to automated platforms; Independently design experiments and analyze data; and Provide technical advice and mentoring to junior  team members. 

Requirements: Bachelor’s degree in Engineering, Physics, Chemistry, Chemical Biology, Computational Biology, Automated Science, or a related field is required and 3 years’ experience as a Clinical Laboratory Automation Specialist, Assay Development Automation Engineer, Molecular Diagnostics Automation Specialist, NGS Workflow Engineer, or related. Must also possess: 3 years’ experience in laboratory automation, preferably in a clinical or diagnostic setting; 3 years’ experience in independent execution of projects for high-throughput diagnostic assay scale-ups; 3 years’ experience in liquid handling platforms (e.g., Hamilton, Beckman Biomek, Agilent Bravo); 3 years’ experience in next-generation sequencing (NGS) workflows and library preparation; 3 years’ experience in conducting independent data analysis/computational tasks; 3 years’ experience with scheduling software such as Biosero Green Button Go or PAA Overlord; 3 years’ experience with programming in Python, R, and bash; 3 years’ experience with CLIA and CAP regulations; and 3 years’ experience in optimizing automated workflows for increased efficiency and yield. Must successfully complete competency-based interview.

ALTERNATE REQUIREMENTS: Master’s degree in Engineering, Physics, Chemistry, Chemical Biology, Computational Biology, Automated Science, or a related field is required and 1 year of experience as a Clinical Laboratory Automation Specialist, Assay Development Automation Engineer, Molecular Diagnostics Automation Specialist, NGS Workflow Engineer, or related. Must also possess: 1 year of experience in laboratory automation, preferably in a clinical or diagnostic setting; 1 year of experience in independent execution of projects for high-throughput diagnostic assay scale-ups; 1 year of experience in liquid handling platforms (e.g., Hamilton, Beckman Biomek, Agilent Bravo); 1 year of experience in next-generation sequencing (NGS) workflows and library preparation; 1 year of experience in conducting independent data analysis/computational tasks; 1 year of experience with scheduling software such as Biosero Green Button Go or PAA Overlord; 1 year of experience with programming in Python, R, and bash; 1 year of experience with CLIA and CAP regulations; and 1 year of experience in optimizing automated workflows for increased efficiency and yield. Must successfully complete competency-based interview.

Expected salary range is $121,264.00-$140,454.00/year. To apply, send resume to recruiting@billiontoone.com.

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BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA,a breakthrough that has already transformed the lives of over half a million patients worldwide.

Our Impact

Unity Complete™ is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. Our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth

From $0 to $150M+ in Annual Recurring Revenue in just five years. In 2025, we completed one of the most successful IPOs for a medical diagnostics company, building on nearly $400M in private funding,including our $130M Series D in 2024 and backed by world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition

Forbes named us one of America's Best Startup Employers for 2025 and we're Great Place to Work certified, with 100% of our people willing to go the extra mile, even as we've scaled to over 700 employees.

Our Future

Headquartered in Menlo Park with facilities in Union City, CA, and a new lab opening in Austin, TX in 2027, we're continuing to push the boundaries of what's possible in molecular diagnostics. We're just getting started.

Ready to help us change the world, one molecule at a time? Learn more at billiontoone.com