AI/ML Research Scientist, Inverse Problems & Machine Learning

Biohub is leading the new era of AI-powered biology to cure or prevent disease through its 501c3 medical research organization, with the support of the Chan Zuckerberg Initiative.

The Team

The Biohub is a group of nonprofit research institutes that bring together scientists, engineers, and physicians with the goal of pursuing grand scientific challenges on 10- to 15-year time horizons. The Biohub focuses on understanding underlying mechanisms of disease and developing new technologies that will lead to actionable diagnostics and effective therapies.

Our Vision

• We pursue large scientific challenges that cannot be pursued in conventional environments
• We enable individual investigators to pursue their riskiest and most innovative ideas
• The technologies developed at the Biohub facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

The Opportunity

The Biohub will create breakthrough technologies — hardware, software, biological probes, data, and platforms — that will be made available to the scientific community and adopted worldwide through a combination of direct access to the institute, open sharing of advances, and commercial partnerships. Researchers will collaboratively develop breakthrough biological imaging systems centered around grand challenges that push the boundaries of what we can see and measure.

We are seeking a creative and motivated Data Scientist to develop and apply cutting-edge computational methods for complex imaging problems. This role is ideal for candidates with expertise in applied mathematics, computational science, or physics, combined with modern machine learning approaches. You will design algorithms, build scalable tools, and collaborate across disciplines to advance scientific discovery.

This position is on-site in Redwood City, CA.

What You'll Do

• Develop and apply algorithms for solving inverse problems in imaging and related computational challenges.
• Use optimization, applied mathematics, and physics-inspired modeling to extract insights from high-dimensional data.
• Incorporate modern machine learning and deep learning techniques to improve reconstruction, denoising, and feature detection.
• Build robust, scalable pipelines for large-scale biological datasets.
• Collaborate with biologists, microscopists, and engineers to design solutions aligned with scientific goals.
• Contribute to technical documentation, publications, and presentations.

What You'll Bring

• M.S. or Ph.D. in Applied Mathematics, Computer Science, Physics, Engineering, or a related field.
• 1 - 5 years of relevant experience.
• Strong foundation in inverse problems, optimization, or computational modeling.
• Experience in machine learning and deep learning (e.g., PyTorch, TensorFlow).
• Proficiency in Python or C++, and familiarity with scientific computing libraries.
• Strong analytical, problem-solving, and communication skills.
• Experience with imaging data (e.g., cryo-EM, tomography, or related modalities).
• Familiarity with convex optimization, variational methods, or numerical PDEs.
• Knowledge of GPU computing and high-performance environments.
• Track record of scientific publications or open-source contributions.

Compensation

The Redwood City, CA base pay range for a new hire in this role is $169,000.00 - $232,100.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. 

Better Together

As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is an onsite position requiring you to be onsite for approximately 4 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process.

Benefits for the Whole You 

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. 

• Provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Paid time off to volunteer at an organization of your choice. 
• Funding for select family-forming benefits. 
• Relocation support for employees who need assistance moving

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

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