Job Application for Director, Clinical Science at Blueprint Medicines

How will your role help us transform hope into reality?

The Director, Clinical Science will provide scientific support for all Clinical Development activities involving the conduct of clinical studies, including: clinical development plans, study design and feasibility, data collection requirements, analysis plans, preparation of meeting materials and internal/external presentations, lead development of key clinical documents (protocol/amendments, IB, CSR), safety and medical review, reporting of study results, and reviewing and summarizing relevant literature. Analyze and synthesize information to assess issues relating to protocol conduct and/or individual subject safety and assist in communicating a clear overview of trial results. You will report to the Sr. Director, Clinical Development and will collaborate with Clinical Pharmacology, Clinical Research, Translational Medicine, Regulatory Affairs, Biostatistics, Data Management and other functions as appropriate.

What will you do?

Work closely with Medical Directors, Pharmacology, Discovery, external experts, and investigators to accumulate scientific and medical knowledge necessary to support clinical development plans and study designs and protocols
Assist Medical Directors in creation of proposed concept sheets for clinical studies and author protocols through incorporation of input from both internal and external experts
Leads the annual update of IB with input from Toxicology, Pharmacology, Safety, Regulatory
Review and interpret biomarker data and help revise clinical development strategy based upon results
Author clinical protocols, amendments and investigators brochures with input from internal and external experts as appropriate, clinical abstracts for presentations at conferences when appropriate and provide input into informed consents documents
Drive and integrates clinical contribution to answering regulatory queries and other submissions related to studies
Monitor and review along with the medical monitor safety and efficacy data in ongoing clinical trials; monitors GCP compliance with help of clinical operations and CRO
Involved in high level data cleaning activities requiring interpretation and clinical judgment
Involved in analysis of complex data for regulatory submissions, publications and design of studies and programs
Attend scientific meetings to remain abreast of new developments within relevant areas and to interact with investigators, and advisors
Work with investigative sites to answer protocol related questions, resolve study conduct and design issues
Coach, mentor and supervise other Clinical Scientists
Present data, protocol designs and other information at advisory boards, investigator meetings, site initiations and other internal and external settings
Reviewer of CRFs, SAPs, TLFs, study manuals impacting endpoint assessment/data collection/analysis (ie, central imaging review charter, blinding plan, data transfer plans for central labs, etc.)
Provide scientific and clinical development input into all other program documents in support of the development plan, including but not limited to informed consent forms (ICF), case report forms (CRF), statistical analysis plans (SAP), and clinical pharmacology/translational medicine plans
Conduct literature and database research on providing background data for clinical trials, and regulatory documents as needed.

What minimum qualifications do we require?

Advanced degree required (M.S., PharmD, or Ph.D.)
7+ years of clinical drug development experience

What additional qualifications will make you a stronger candidate?

Degree in scientific/life sciences/clinical/nursing field is preferred
Prior hematology or oncology drug development experience a plus
Ability to work in a highly collaborative, matrix environment with the ability to manage through conflict resolution
Excellent written and oral communication skills
Strong analytical ability, detail oriented, and proficiency in data management a plus
Commitment to our Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism

Why Blueprint?

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it.

Patients are waiting. Are you ready to make the leap?

Equity, Diversity, Inclusion and Affirmative Action

At Blueprint Medicines, we foster a culture of equity, diversity and inclusion. A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law. We are also an E-Verify Employer. We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out to TotalRewards@blueprintmedicines.com.

For more information, please see our EEO-AA Policy Statement, the EEO Know Your Rights Poster, as well as our Pay Transparency Statement.

Blueprint Medicines is a global, fully integrated biopharmaceutical company that invents life-changing medicines. We seek to alleviate human suffering by solving important medical problems in two core focus areas: allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a proven track record of success with two approved medicines, including bringing our medicine to patients with systemic mastocytosis (SM) in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we now aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases including SM and chronic urticaria, breast cancer and other solid tumors.

#LI-Hybrid

#LI-AQ1

First Name

Last Name

Phone

Resume/CV*

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter

Accepted file types: pdf, doc, docx, txt, rtf

LinkedIn Profile

Website

Recruitment Documentation

Accepted file types: pdf, doc, docx, txt, rtf

Please attach any additional recruitment documentation you would like considered in your application (i.e. cover letter, letter of reference or publications).

Are you subject to any non-competition agreement or restrictive covenant that may prevent or limit your ability to work for Blueprint Medicines?

Select...

Will you now or in the future require sponsorship for employment visa status?

Select...

Are you legally authorized to work in the United States?

Select...

Are you currently providing or have you ever provided services to Blueprint Medicines as a contractor or as an employee of another entity?

Select...

I agree to receive updates about new job opportunities matching my applicant profile and marketing communications.

Select...

Please read the Privacy Policy to understand how Blueprint Medicines may collect and process personal data associated with your application.

I agree that all written and verbal information I provide in connection with my application and candidacy is and will be accurate and truthful to the best of my knowledge, and that any omissions or mispresentations by me will result in the discontinuance of my candidacy, withdrawal of any offer of employment, or termination of my employment.

Select...

We Invite You to Tell Us More About Yourself

At Blueprint Medicines, we foster a culture of equity, diversity and inclusion to empower the Blue Crew to bring their authentic selves to work. A proud Equal Employment Opportunity and Affirmative Action employer, we consider all applicants without regard to any status protected under applicable law and we strive to employ qualified diverse talent. We encourage you to share information about yourself by answering the questions below, to help us comply with federal government reporting and recordkeeping requirements, evolve our ED&I initiatives, and measure the effectiveness of our efforts. Please review the Government Ethnicity and Race Definitions when answering those questions below.

Although all sections below require a response, you can always select "I don't wish to answer." Your responses will be kept confidential and used only in a manner consistent with applicable law and will never be used against you. Thank you for sharing more about yourself and contributing to our affirmative action and diversity efforts.

Voluntary Self-Identification of Protected Veteran Status

Blueprint Medicines is a government contractor subject to the Vietnam Era Veterans' Readjustment Assistance Act of 1974, as amended by the Jobs for Veterans Act of 2002, 38 U.S.C. 4212 (VEVRAA). As such, we take affirmative action to employ and advance in employment protected veterans, including by reaching out to veterans' groups for qualified applicants and periodically reviewing our processes to ensure there are no unintended barriers. To help us measure the effectiveness of our outreach and recruitment efforts of veterans, we ask you to share if you are a veteran covered by VEVRAA. Answering is completely voluntary, but we hope you will do so, and your response will be used and kept confidential consistent with VEVRAA, and will not be used against you in any way. Please review these Protected Veteran Descriptions and check the appropriate box further below as to whether you belong to any of these government-defined categories.

Voluntary Self-Identification of Disability

Form CC-305 OMB Control Number 1250-0005
Page 1 of 1 Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

Alcohol or other substance use disorder (not currently using drugs illegally)
Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
Blind or low vision
Cancer (past or present)
Cardiovascular or heart disease
Celiac disease
Cerebral palsy
Deaf or serious difficulty hearing
Diabetes
Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
Epilepsy or other seizure disorder
Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
Intellectual or developmental disability
Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
Missing limbs or partially missing limbs
Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
Partial or complete paralysis (any cause)
Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
Short stature (dwarfism)
Traumatic brain injury

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.

Please check one of the boxes below:

Please check one of these boxes:

Select...

Please identify your protected veteran status:

Select...

Are you of Hispanic or Latino ethnicity?

Select...

Please select the race(s) you identify with:

Select...

Please identify your gender (Select all that apply):

Select...

Please identify your sexual orientation:

Select...

Director, Clinical Science

Apply for this job

We Invite You to Tell Us More About Yourself

Voluntary Self-Identification of Disability