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Sr. Director, Marketing GIST

Waltham, Massachusetts, United States

Who We Are:

Cogent Biosciences is a publicly traded biotechnology company dedicated to developing precision therapies for genetically defined diseases. By leveraging validated biology and a rational drug discovery approach, Cogent aims to create real solutions that address the underlying drivers of disease and offer meaningful hope to patient's.

The company’s lead therapeutic candidate, bezuclastinib, is a highly selective tyrosine kinase inhibitor designed to potently target KIT D816V and other mutations in KIT exon 17. These mutations are known drivers of systemic mastocytosis (SM) and advanced gastrointestinal stromal tumors (GIST) - both serious conditions driven by oncogenic KIT signaling. Bezuclastinib is currently being evaluated in multiple registration-directed trials across Non-Advanced SM (NonAdvSM), Advanced SM (AdvSM), and GIST.  In July 2025, Cogent announced that its registration-direct SUMMIT trial in patients with NonAdvSM achieved statistical significance across all primary and key secondary endpoints, and the company is on track to file its first New Drug Application for this patient population by the end of 2025.  The company also remains on track to announce top-line results for its APEX trial in patients with AdvSM in the second half of 2025 and for its PEAK trial in patients with GIST by the end of 2025.  The company also has an ongoing Phase 1 study of its novel internally discovered FGFR2 inhibitor, and the Cogent Research Team is developing a portfolio of novel targeted therapies to help patients fighting other serious, genetically driven diseases targeting mutations in ErbB2, PI3Kα and KRAS.

Through its commitment to precision medicine and targeted innovation, Cogent Biosciences is working to transform the treatment landscape for patients with serious and underserved diseases. By leveraging validated biology and a rational drug discovery approach, Cogent aims to create real solutions that address the underlying drivers of disease. Our culture of inquisitiveness fuels continuous learning and innovation; we challenge assumptions, ask bold questions, and embrace a mindset of discovery to uncover transformative insights.

The Role: 

This position will report to the Vice President of Marketing and offers an extraordinary opportunity for individuals interested in joining a company on the verge of it’s first product launch with outstanding data in rare disease and oncology indications. This is a rare opportunity to lead the launch of Bezuclastinib in 2L Gastrointestinal Stromal Tumor (GIST) indication. Bezuclastinib represents the most transformative advancement in GIST in the last 20 years. The Senior Director of Marketing is recognized as an internal expert in GIST disease, market and promotions. The individual is responsible for developing brand strategy for the GIST indication and leading a comprehensive HCP marketing program for bezuclastinib in the US. The individual will lead HCP marketing initiatives and work closely with the cross-functional team to develop and execute marketing strategies that promote brand and company goals. As an in-house expert on HCP marketing and GIST, this person will provide leadership and guidance to the current team and cross functional partners on marketing activities, strategic and competitive planning, strategic and tactical plan execution, segmented marketing capabilities/execution, digital and omni-channel marketing to HCPs. This individual will ensure tactics and capabilities provide ongoing measurement and optimization at each stage and that resources (dollars and FTE effort) are aligned. The successful candidate will contribute in-depth marketing expertise, work closely with internal stakeholders up to executive levels and external partners (including creative agencies, operational partners, medical and diagnostics teams, analytics teams), with the capacity to develop a tactical plan with budget, resourcing, and implementation plan to support the needs of the business.

 
Responsibilities:
  • Internal marketing leader and subject matter expert in GIST.
  • Leads the development of HCP strategic plans and promotion with measurable outcomes to achieve business/product goals. Presenting plans to executive leadership/other stakeholders.
  • Leads the development of tactical plans that will achieve the goals set forth in the marketing strategy.
  • Collaborate closely with field sales team including sales leadership, sales training & field representatives, to ensure execution of marketing strategies and tactics.
  • Lead the HCP marketing efforts and oversee their execution.
  • Build and implement best in industry capabilities for segmented channel marketing while collaborating with key internal stakeholders and external strategic partners.
  • Continually monitor/analyze marketing trends and technologies that impact the lives of patients and HCPs; identifies and introduces marketing innovations to the organization.
  • Works cross-functionally including with counterpart leading GIST indication, to help teams develop and evolve marketing ideas that promote brand goals while ensuring strict compliance with regulations and guidelines.
  • Demonstrates agility and flexibility, as part of a nimble, entrepreneurial organization.
  • Develops impactful and relevant strategies for multiple audiences (e.g., KOL Oncologists, Community Oncologists, Oncology Nurses) throughout the product lifecycle.
  • Develops budget/resourcing plan for the HCP marketing function and tracks financial spending and adjustments with high acumen.
  • Establishes and communicates Key Performance Indicators (KPIs) both to internal staff and external partners/agencies. Provides continuous monitoring/reporting/optimization against KPIs.
  • When appropriate, identifies potential external partners, 3rd parties, and collaborates on contract negotiations to write contracts sensitive to bottom-line business goals.
  • Performs effective Agency of Record and vendor management; ensures appropriate balance of internal and external resources to drive campaign execution in a manner that achieves best ROI.
  • Provides campaign analysis and aids in marketing mix analyses; identifies marketing “best practices” and helps disseminate them throughout the organization. Identifies areas for improvement on subsequent campaigns and investments.
  • Coordinates the work of agencies of record, multiple external vendors and internal departments including marketing, analytics, operations, legal, regulatory, medical affairs, compliance, and IT.
  • Demonstrate leadership with internal customer-facing teams, specifically with sales and sales training to ensure effective, impactful, world-class training on promotional tools and programs as well as support of national and regional internal sales/commercial meetings to elevate effectiveness of marketing campaigns and share best practices.

Qualifications:

 

  • Bachelor’s Degree required, MBA or other advanced degree preferred
  • US Oncology Marketing & launch experience preferred (knowledge of current competitive landscape, therapies and practices, testing landscape and biomarkers)
  • Minimum 10 years of progressive experience in the Pharmaceutical/Biotech industry in Marketing, Sales, and/or Business Development, preferably in both small and large companies
  • Demonstrate confidence and comfort in dealing with executive leadership
  • Sales Experience a plus – either at the representative or line manager level
  • 5 years of Brand Management specifically with recent in-depth experience in brand leadership with deep US commercialization background
  • Comfortable engaging with KOLs and able to conduct a deep thorough scientific discussion
  • Experience as a team/people leader
  • Recent (1-3 years) rare disease and/or oncology launch experience strongly preferred
  • Demonstrated analytical skills and the ability to think strategically and solve problems
  • Outstanding project management skills and experience managing multiple vendors and agency partners and ability to effectively manage multiple competing priorities simultaneously
  • Proven track record of working effectively with regulatory, legal and medical teams in approval of multiple promotional materials
  • Significant experience in managing budgets including assessing level of investment, tactical planning, budget allocation, timely initiation of projects and billing to keep on track against planned targets
  • Some travel required (up to 25%).
  • Location: Waltham, MA (surrounding areas) required.

Salary Range:

$250,000 - $290,000 USD 

Target Bonus: 25%
Exact compensation will vary based on skills, experience, and location.
 
Our Locations
 
Waltham, MA: Our Boston office includes an open office layout that has recently undergone a makeover designed for collaboration and giving our employees the best work place possible. Free access is provided for both on-site parking and gym facilities in the building.
 
Boulder, CO: We have just moved into our new state-of-the art Research Facility in the fast-growing biopharmaceutical hub in the greater Denver/Boulder corridor.  Our CEO is based full-time in this location and we are proud to call this the home of Cogent’s discovery research organization.
 
Our Offer To You
 
To attract the very best talent, we offer a generous benefits package that includes competitive pay, performance-based bonus, stock options, insurance coverage (health, dental, life, and disability), competitive time-off, a 401(k) plan, and commuter/parking benefits.
 
We are proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability, or any other status protected under federal, state, or local law. All employment is decided on the basis of qualifications, merit, and business need.

 

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