Postdoctoral Fellow, Functional Immunogenomics (Biohub Chicago)

The Chan Zuckerberg Biohub Chicago (https://www.czbiohub.org/chi) is an independent nonprofit research institute that brings together three powerhouse universities - Northwestern University, the University of Chicago, and the University of Illinois Urbana-Champaign - into a single collaborative technology and discovery engine. CZ Biohub itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to make breakthroughs in medicine and develop new technologies, frequently in collaboration with our partner universities. We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.

Our Vision

• We pursue large scientific challenges that cannot be pursued in conventional environments
• We enable individual investigators to pursue their riskiest and most innovative ideas
• The technologies developed at CZ Biohub Chicago facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of CZ Biohub Network and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

The Opportunity

The Chan Zuckerberg Biohub Chicago is seeking outstanding early-career scientists to join and participate in the launch of the Biohub Chicago by continuing their training as Postdoctoral Fellow for the  Functional Immunogenomics team.  

What You'll Do

• Generate knockout (KO), knock-in (KI), and overexpression cell models for functional and phenotypic hit validation
• Develop and optimize multi-color flow cytometry-based assays to analyze cell surface markers, intracellular cytokines, and other functional parameters in primary or iPSC-derived immune cells
• Culture, maintain, and genetically manipulate primary and immortalized cell lines from skin, immune, and neuronal origins
• Collaborate with a multidisciplinary team — including experts in engineering, functional genomics, bioinformatics, and disease biology — to contribute to hit validation and technology development projects
• Maintain accurate, thorough, and well-organized documentation of all experiments and protocols

You have 

Essential -

• PhD in a relevant discipline of life sciences 
• 0-2 years of postdoctoral experience
• 1 years of CRISPR experience
• A first-author publication (published or in-press) in immunology or a related field that demonstrates strong critical thinking and experimental design skills
• Hands-on experience with multi-color flow cytometry and culture of primary immune cells (e.g., macrophages, NK cells, T cells)
• Familiarity with CRISPR technologies and delivery methods, including lentiviral vectors and RNPs

Nice to have - 

• Experience with murine models, including handling and dosing
• Exposure to single-cell omics, spatial transcriptomics, and/or high-content imaging data analysis

Compensation

The Chicago, IL base pay range for this role is $75,000.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. 

What We Provide 

• Resources to disrupt and innovate at the frontiers of our knowledge of biology and disease
• A collegial and collaborative environment consisting of diverse expertise
• Access to collaborators, resources and facilities at our three partner universities (Northwestern University, the University of Chicago, and the University of Illinois Urbana-Champaign) and at partner organizations in Chicagoland and beyond
• Competitive compensation and benefits commensurate with the experience

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

Benefits

We offer a robust benefits program that enables the important work Biohubbers do everyday. Our benefits include healthcare coverage, life and disability insurance, commuter subsidies, family planning services with fertility care, childcare stipend, 401(k) match, flexible time off and a generous parental leave policy. In addition, we honor our commitment to career development and our value of scholarly excellence through regular onsite opportunities to learn from the world's leading scientists.

The CZ Biohub Network is an equal opportunity employer committed to diversity of thought, ideas and perspectives. We are committed to cultivating an inclusive organization where all Biohubbers feel inspired and know their work makes an important contribution. Therefore, we provide employment opportunities without regard to age, race, color, ancestry, national origin, religion, disability, sex, gender identity or expression, sexual orientation, or any other protected status in accordance with applicable law.

Headhunters and recruitment agencies may not submit resumes/CVs through this website or directly to managers. The CZ Biohub Network does not accept unsolicited headhunter and agency resumes. The CZ Biohub Network will not pay fees to any third-party agency or company that does not have a signed agreement with the CZ Biohub Network.