Vice President, Sales - Neuroscience

Definium Therapeutics is a late-stage clinical biopharmaceutical and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.  

Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.     

Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX. 

Together we are moving psychiatry forward—beyond better, into a boundless future. Join us!

We are seeking an experienced and visionary Vice President of Sales to lead the sales field team and sales training efforts in preparation for the potential commercial launch of DT120. This senior leadership role will focus on building and scaling a high-performing sales organization while driving successful product launches in the psychiatry space.

Reporting to the Chief Commercial Officer, the ideal candidate will have proven expertise launching products in the neuroscience or CNS therapeutic area (ideally with experience in complex and/or REMS products), a strong track record of building high-caliber sales teams as a Vice President, and the ability to foster a collaborative, positive sales culture grounded in the highest integrity. This role involves cross-functional coordination with other field teams (i.e. reimbursement specialists, site readiness team, and others).

This is a high-impact, hands-on leadership position for a strategic sales leader passionate about advancing transformative treatments for brain health.

Key Responsibilities

• Build and Lead the Sales Field Team: Recruit, develop, mentor, and retain a high-caliber national sales team. Provide ongoing coaching, performance management, and leadership to ensure the team meets or exceeds sales targets
• Oversee Sales Training: Design, implement, and continuously improve comprehensive sales training programs to equip the field team with deep product knowledge, selling skills, and expertise in the neuroscience/CNS landscape
• Drive Product Launch: Lead the execution of sales strategies and tactical plans for DT120, contributing to rapid market adoption and revenue growth
• Cross-Functional Coordination: Partner closely with the commercial operations team and other functions to ensure territory mapping, deployment scenarios, and resource allocation are adequate and optimized. Facilitate effective collaboration across commercial teams (e.g., with marketing, medical affairs, and market access) to support integrated pull-through initiatives
• REMS and Specialty Expertise: Apply experience with Risk Evaluation and Mitigation Strategy (REMS) programs or other complex distribution models to guide compliant and effective sales execution
• Foster Sales Culture: Cultivate a collaborative, inclusive, and high-integrity sales culture that emphasizes ethical practices, accountability, teamwork, and a patient-centric mindset
• Performance Management & Insights: Establish clear KPIs, monitor field performance, and provide regular feedback and adjustments. Share field insights with cross-functional partners to refine commercial strategies
• Compliance: Ensure all sales activities adhere to the highest ethical standards, regulatory requirements, and company policies

Qualifications:

• Bachelor’s degree required; advanced degree (MBA, PharmD, or related) strongly preferred
• Minimum 15 years of progressive pharmaceutical/biotech sales leadership experience, with at least 3 years in a Vice President of Sales (or equivalent senior sales leadership) role
• Proven track record of successfully building and leading sales field teams from planning through launch and growth
• Direct experience launching products in the neuroscience, CNS, or psychiatry therapeutic area
• Hands-on experience with REMS programs or other highly regulated/complex commercialization models
• Demonstrated success in cross-functional coordination with commercial operations, reimbursement, market access, or site-of-care teams (without direct line management of those functions)
• Leadership & Personal Attributes:
  • Exceptional ability to build, inspire, and develop high-performing sales teams
  • Highest level of personal and professional integrity
  • Strong collaborator who excels at cross-functional partnerships
  • Strategic thinker with excellent communication, influencing, and analytical skills
  • Passion for mental health innovation and patient-centered sales execution
• Willingness to travel extensively (up to 50–70%) to support the field team, training initiatives, and key stakeholders

What We Offer

• Competitive compensation package, including base salary, performance bonus, equity, and comprehensive benefits.
• Opportunity to play a pivotal role in building the sales foundation for groundbreaking therapies that could transform psychiatry.
• Collaborative, mission-driven culture at a company with a high-profile late-stage pipeline and significant 2026 catalysts.

The starting base pay range for this position is $322,103.00 - $380,000.00. Compensation will be determined based on several factors including, but not limited to, skill set, years of experience, and the employee’s geographic location.

Employees in this role may be entitled to additional compensation, including bonus and equity. Benefits information is listed on our Jobs Page. The Company provides competitive benefits to employees including:

• 100% paid health benefits including Medical, Dental and Vision for you and your dependents
• 401(k) program with company match and vesting after the turn of the first month after your start date
• Flexible time off
• Generous parental leave and some fun fringe perks!