Senior Principal Clinical Scientist

Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA. 

COMPANY OVERVIEW:

Disc Medicine is a clinical-stage biopharmaceutical company committed to discovering, developing, and commercializing novel treatments for patients who suffer from serious hematologic diseases. We are building a portfolio of innovative, first-in-class therapeutic candidates that aim to address a wide spectrum of hematologic diseases by targeting fundamental biological pathways of red blood cell biology, specifically heme biosynthesis and iron homeostasis. Disc Medicine values collaboration, professional development, and scientific integrity and promotes an inclusive company culture that empowers and inspires.

POSITION OVERVIEW:

Reporting to the Senior Medical Director, this is a unique and exciting opportunity for an ambitious clinical scientist interested in working at a fast-paced and growing biotech company. This position will primarily support the DISC-3405 program focused on hepcidin induction and iron restriction. Additional responsibilities in scope are dependent on the candidate’s interests and previous experience. The Clinical Scientist will work with an energized cross-functional program team and help drive the clinical program from early to late-stage studies.

RESPONSIBILITIES:

• Work directly with the Medical Director and the clinical study team in the execution of early-stage Phase 1 & 2, as well as pivotal, clinical trials
• Collaborate cross-functionally with Medical Directors, Pharmacology, Innovation, Pharmacovigilance, external experts, and investigators to accumulate scientific, medical, and safety knowledge necessary to support clinical development plans, study designs, investigator brochures, and protocols
• Work closely with contract research organizations and the internal Disc team to strategize and meet timelines
• Monitor and review safety and efficacy data in ongoing studies with the Medical Monitor
• Represent the clinical study team at the clinical sub team and program team meetings and collaborate with the clinical team to lead data capture and analysis
• Develop and maintain relationships with key opinion leaders and principal investigators
• Participate in Investigator meeting planning and execution and/or on-site initiation meetings
• Lead internal and external team members, vendors, and consultants to develop, review and evaluate efficacy and safety data for external presentation and regulatory submissions
• Review and content of clinical and regulatory documents, including protocols, INDs, CTAs, investigator brochures, CRFs, annual IND reports, CSRs, and clinical expert reports
• Organize and present at clinical advisory boards, investigator meetings, DMC and SRC meetings, and medical/scientific meetings
• Support strategy and business development processes for in- or out-licensing, partnering and acquisition activities
• Maintain awareness of internal and external developments (scientific, clinical, competitive, and regulatory) including attendance at major scientific conferences, participation in competitive intelligence activities, and periodic literature review
• Critically evaluate available information about diseases of interest to the therapeutic area and the competitive landscape while synthesizing information to support its dissemination and incorporation into clinical development, asset plans, and therapeutic area strategy
• Travel periodically both nationally and internationally

 REQUIREMENTS:

• PhD, PharmD, or MD with research experience
• 12+ years of related experience in translational or clinical research related to drug development. Inhouse biotech/ pharma experience preferred
• Knowledge in the principles of clinical research methodology, statistics, data analysis and interpretation and ability to think strategically and analyze data while executing study responsibilities
• Willingness to take on new responsibilities and expand professional skills and experience and able to execute in a high-paced environment
• Experience with developing clinical regulatory strategy
• Ability to identify and build relationships with thought leaders and leading clinical centers
• Strong academic record demonstrating research productivity is a plus
• Track record of effective cross-collaboration within an organization, among teams, and external groups/organizations
• Ability to clearly and effectively communicate to internal and external stakeholders orally and in writing
• Experience in interacting with varying levels of internal/external management, academicians, clinicians, scientists, etc.
• Strong business acumen; including in-depth knowledge of the multidisciplinary functions involved in a company’s drug development process, e.g., clinical operations, biostatistics, regulatory, commercial operations, etc. and can proactively integrate multiple perspectives into the clinical development process for best end-results

Disc Medicine is an equal-opportunity employer committed to providing all qualified candidates and employees equal opportunities. We offer comprehensive benefits and competitive compensation packages. The Company headquarters are in Watertown, MA, and we provide a flexible work environment. 

Disc Medicine actively recruits individuals with an entrepreneurial spirit and a drive for excellence. Interested candidates should submit a cover letter and resume to be considered for current and future opportunities.