Corporate Accounting Manager

Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA. 

COMPANY OVERVIEW:

Disc Medicine is a clinical-stage biopharmaceutical company committed to discovering, developing, and commercializing novel treatments for patients who suffer from serious hematologic diseases. We are building a portfolio of innovative, first-in-class therapeutic candidates that aim to address a wide spectrum of hematologic diseases by targeting fundamental biological pathways of red blood cell biology, specifically heme biosynthesis and iron homeostasis. Disc Medicine values collaboration, professional development, and scientific integrity and promotes an inclusive company culture that empowers and inspires.

POSITION OVERVIEW:

Disc Medicine is seeking a highly skilled Corporate Accounting Manager to join its Finance organization and support the company’s financial reporting, control, and compliance requirements as a public, clinical stage biopharmaceutical company. Reporting to the Director of Accounting, this role will be responsible for leading critical components of the monthly, quarterly, and annual close processes; ensuring accurate and timely financial reporting in accordance with U.S. GAAP; and maintaining an effective internal control environment in compliance with Section 404(b) of the Sarbanes Oxley Act.

The Corporate Accounting Manager will oversee general ledger activities, including the preparation and review of complex journal entries, account reconciliations, and variance analyses, and will manage accrual processes across research, clinical operations, CMC, G&A, and commercial functions. This position will partner closely with FP&A and cross functional stakeholders to validate spend, support forecasting and budgeting activities, and develop and maintain clinical trial accrual models to ensure appropriate recognition of costs incurred.

In addition, the Corporate Accounting Manager will serve as a key liaison for internal and external auditors, supporting integrated audits and quarterly reviews through the execution, documentation, and testing of internal controls, as well as the preparation of audit schedules and supporting materials. The ideal candidate brings strong technical accounting knowledge, a disciplined approach to controls and compliance, and the ability to operate effectively in a fast paced, evolving public company environment while contributing to continuous improvement of accounting processes and systems.

RESPONSIBILITIES:

• Play a lead role in the monthly, quarterly, and annual close processes, ensuring timely and accurate financial reporting.
• Understands and applies U.S. GAAP, has strong internal control structure understanding and has willingness to challenge current processes or procedures as a trusted business partner.
• Prepares / reviews complex journal entries, account reconciliations, and variance analyses with a high degree of accuracy managing the monthly, quarterly, and year‑end close processes, ensuring timely and accurate financial reporting in accordance with US GAAP.
• Lead the monthly accrual process across research, clinical operations, CMC, G&A, and commercial functions, ensuring expense recognition reflects operational activity.
• Partner closely with FP&A, Clinical Operations, CMC, and other cross‑functional teams to validate spend and inform accrual estimates.
• Develop, maintain, and review clinical accrual models for multiple clinical programs across various phases, ensuring accurate recognition of costs incurred but not yet invoiced.
• Serve as a key point of contact for interim and year-end internal and external integrated audits, preparation of schedules, performance / documentation of controls and providing supporting documents.
• Analyze and explain variances between actual results, forecasts, and budgets to management and external auditors.
• Other duties as assigned.

 REQUIREMENTS:

• Bachelor’s degree in Accounting, Finance or related field
• 5+ years of progressive accounting experience, typically including a combination of public accounting and biotechnology or life sciences industry experience.
• Strong knowledge of US GAAP, Certified Public Accountant (CPA) is preferred
• Excellent communication and interpersonal skills, with the ability to collaborate effectively across functional teams.
• Demonstrated ability to work in a dynamic and rapidly changing environment and the flexibility to handle multiple priorities simultaneously.
• Experience with ERP systems such as NetSuite and Coupa (preferred). Advanced Excel skills required.
• Minimum of 3 years of experience (either as an auditor or in industry) with internal controls under Section 404(b) of the Sarbanes-Oxley Act (SOX). Working knowledge of drug development process within the biotech/pharmaceutical industry, including clinical trial accruals is required.

Disc Medicine is an equal-opportunity employer committed to providing all qualified candidates and employees equal opportunities. We offer comprehensive benefits and competitive compensation packages. The Company headquarters are in Watertown, MA, and we provide a flexible work environment. 

Disc Medicine actively recruits individuals with an entrepreneurial spirit and a drive for excellence. Interested candidates should submit a cover letter and resume to be considered for current and future opportunities.

Disc Medicine respects your privacy.  For information about how Disc processes your personal data in the context of your candidacy, please see our Privacy Notice.