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Senior Associate Engineer, Downstream Process Development

Waltham, Massachusetts, United States

Senior Associate Engineer, Downstream Process Development

Dragonfly Therapeutics seeks a Senior Associate Engineer, Downstream who can make an immediate impact on our high performing CMC team. We are searching for enthusiastic, and innovative individual with a deep scientific interest in drug development, who thrive in a fast-paced, entrepreneurial environment. As such, the candidate must be goal-oriented, flexible, and able to work collaboratively across multiple projects with colleagues from research and development.

Responsibilities (including but not limited to):

  • Develop and execute robust, scalable downstream processes for Dragonfly’s novel multi-specific antibody and cytokine platforms ranging from chromatography to tangential flow and viral filtration
  • Run routine analytics including HPLC and capillary electrophoresis and analyze/summarize results
  • Design and improve processes related to protein recovery, scalability and purity
  • Prepare technical reports, SOPs, internal and external presentations
  • Identify, evaluate, and implement new and existing technologies to improve process efficiency, control, and understanding
  • Perform comprehensive data analysis (through excel or other statistical analysis software such as JMP) and present data, conclusions, and recommendations to the team
  • Ensure effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks
  • Effectively maintain good communication and collaborate with cross-functional colleagues and external partners for successful execution/completion of projects
  • Prepare reagents, buffers, and equipment as needed to support experiments
  • Maintain Downstream PD laboratory to ensure consumables and raw materials are readily available and equipment is calibrated and properly maintained
  • This is a lab-based role, so additional duties and responsibilities will be assigned as required

Qualifications:

  • BS or MS degree in Chemical Engineering, Biochemical Engineering, Biochemistry or equivalent related fields with 3+ years relevant industrial experience required
  • Strong hands-on experience in protein purification techniques such as filtration, chromatography, TFF, UF/DF, AKTA, UNICORN and HPLC systems. Experience with different modes of chromatography is required
  • Prior experience with biochemical characterization of proteins is required
  • Understanding of GxP activities such as reviewing GMP batch records, tech transfer reports, and campaign summary reports is desirable
  • Experience with operating and programming high-throughput liquid handling platforms (e.g. TECAN, Hamilton, etc) is desirable
  • The candidate is self-motivated, accountable, inquisitive, and has excellent organization and communication skills

About Dragonfly

Dragonfly Therapeutics is a clinical-stage biopharmaceutical company committed to discovering, developing and commercializing therapies that use its novel multispecific antibody technology to harness the body's immune system to bring breakthrough treatments to patients. In addition to its wholly owned clinical assets, Dragonfly has a deep pipeline of wholly owned preclinical candidates discovered using its proprietary platform, as well as productive collaborations with Merck, AbbVie, Gilead and Bristol Myers Squibb in a broad range of disease areas. 

Our mission is to revolutionize disease treatment by inventing natural killer cell-based therapies for vastly improved patient outcomes. We believe in a small team with a big impact.

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