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Associate Scientist II/Sr. Associate Scientist

Waltham, Massachusetts, United States

Associate Scientist II / Senior Associate Scientist (Biophysical and Biochemical Characterization)

Dragonfly Therapeutics is seeking an Associate Scientist II / Senior Associate Scientist to join our team (Title commensurate with experience). 

Responsibilities include providing biophysical and biochemical characterization of our candidates to inform lead selection, performing developability assessments, interpreting and summarizing results, authoring technical reports, representing the Protein Sciences function on cross-functional teams. The candidate must be independent, goal-oriented, flexible, and able to work efficiently across multiple projects. We are searching for enthusiastic and innovative individuals with a keen eye for detail, who thrive in a fast-paced, entrepreneurial environment. 

Key Responsibilities: 

  •  Biophysical and Biochemical Characterization: Perform comprehensive protein analytics using techniques such as size-exclusion chromatography (SEC), hydrophobic interaction chromatography (HIC), differential scanning calorimetry (DSC)/differential scanning fluorimetry (DSF), capillary electrophoresis (CE-SDS), and capillary isoelectric focusing (cIEF). 
  • Developability Assessments: Conduct in-depth developability assessments to inform lead candidate selection by evaluating stability, aggregation propensity, and structural integrity. 
  • Data Interpretation and Reporting: Analyze experimental data, provide detailed interpretation, and summarize findings in technical reports. Contribute to internal discussions and external presentations to cross-functional teams. 
  • Documentation and Compliance: Maintain high standards of documentation, ensuring accurate and timely recording of experimental workflows, protocols, and results in electronic laboratory notebooks (ELN). 
  • Reagent Preparation and Equipment Maintenance: Prepare reagents and buffers, maintain lab equipment, and ensure a seamless flow of experiments in support of project timelines. 

  • Cross-Functional Collaboration: Represent the Protein Sciences function on cross-functional project teams, contributing technical expertise and driving alignment on analytical methodologies and project goals. 

Education: 

  • B.Sc. in Biochemistry, Biochemical Engineering, Chemistry, or related discipline, with 2-5 years of relevant industrial experience, or 
  • M.Sc. in Biochemistry, Biochemical Engineering, Chemistry, or related discipline, with 1-4 years of relevant industrial experience. 

Technical Expertise: 

  • Strong hands-on experience with protein analytics techniques such as SEC, HIC, DSC/DSF, CE-SDS, and cIEF. 
  • Proficiency in characterizing post-translational modifications, protein aggregation, and assessing protein stability. 

Skills: 

  • Excellent data analysis and interpretation skills, with familiarity using statistical tools and software for data processing (e.g., GraphPad Prism, Spotfire). 
  • Strong organizational and multitasking abilities, with a keen attention to detail. 
  • Excellent verbal and written communication skills for presenting data and drafting technical reports. 
  • Proactive and collaborative team player with the ability to work independently under minimal supervision. 

 

About Dragonfly

Dragonfly Therapeutics is a clinical-stage biopharmaceutical company committed to discovering, developing and commercializing therapies that use its novel multispecific antibody technology to harness the body's immune system to bring breakthrough treatments to patients. In addition to its wholly owned clinical assets, Dragonfly has a deep pipeline of wholly owned preclinical candidates discovered using its proprietary platform, as well as productive collaborations with Merck, AbbVie, Gilead and Bristol Myers Squibb in a broad range of disease areas. 

Our mission is to revolutionize disease treatment by inventing natural killer cell-based therapies for vastly improved patient outcomes. We believe in a small team with a big impact.

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