Back to jobs
New

Principal Associate Scientist/Scientist I

Waltham, Massachusetts, United States

Associate Scientist II / Senior Associate Scientist (Biophysical and Biochemical Characterization)

Dragonfly Therapeutics is seeking an Principal Associate Scientist/Scientist I to join our team (Title commensurate with experience).

Responsibilities include providing biophysical and biochemical characterization of our candidates to inform lead selection, performing developability assessments, interpreting and summarizing results, authoring technical reports, representing the Protein Sciences function on cross-functional teams. The candidate must be independent, goal-oriented, flexible, and able to work efficiently across multiple projects. We are searching for enthusiastic and innovative individuals with a keen eye for detail, who thrive in a fast-paced, entrepreneurial environment.

Responsibilities (including but not limited to):

  • Biophysical and Biochemical Characterization: Perform comprehensive protein analytics using techniques such as size-exclusion chromatography (SEC-MALS), hydrophobic interaction chromatography (HIC), differential scanning calorimetry (DSC)/differential scanning fluorimetry (DSF), capillary electrophoresis (CE-SDS), and capillary isoelectric focusing (cIEF).
  • Developability Assessments: Plan, coordinate, and conduct in-depth developability assessments to inform lead candidate selection by evaluating stability, aggregation propensity, and structural integrity.
  • Data Interpretation and Reporting: Analyze experimental data, provide detailed interpretation, and summarize findings in technical reports. Contribute to internal discussions and external presentations to cross-functional teams.
  • Assay Development: Maintain awareness of new and emerging analytical methods and assays. Evaluate new methods and, as appropriate, develop them for use in the Protein Analytics toolbox.
  • Documentation and Compliance: Maintain high standards of documentation, ensuring accurate and timely recording of experimental workflows, protocols, and results in electronic laboratory notebooks (ELN).
  • Reagent Preparation and Equipment Maintenance: Prepare reagents and buffers, maintain lab equipment, and ensure a seamless flow of experiments in support of project timelines.
  • Cross-Functional Collaboration: Represent the Protein Sciences function on cross-functional project teams, contributing technical expertise and driving alignment on analytical methodologies and project goals.

Education:

  • Sc. in Biochemistry, Biochemical Engineering, Chemistry, or related discipline, with 8+ years of relevant industrial experience, or
  • Sc. in Biochemistry, Biochemical Engineering, Chemistry, or related discipline, with 6+ years of relevant industrial experience.

Technical Expertise:

  • Strong hands-on experience with protein analytics techniques such as SEC-MALS, HIC, DSC/DSF, CE-SDS, and cIEF.
  • Proficiency in characterizing post-translational modifications, protein aggregation, and assessing protein stability.

Skills:

  •  Excellent data analysis and interpretation skills, with familiarity using statistical tools and software for data processing (e.g., GraphPad Prism, Spotfire).
  • Strong organizational and multitasking abilities, with a keen attention to detail.
  • Excellent verbal and written communication skills for presenting data and drafting technical reports.
  • Proactive and collaborative team player with the ability to work independently under minimal supervision.

 

About Dragonfly

Dragonfly Therapeutics is a clinical-stage biopharmaceutical company committed to discovering, developing and commercializing therapies that use its novel multispecific antibody technology to harness the body's immune system to bring breakthrough treatments to patients. In addition to its wholly owned clinical assets, Dragonfly has a deep pipeline of wholly owned preclinical candidates discovered using its proprietary platform, as well as productive collaborations with Merck, AbbVie, Gilead and Bristol Myers Squibb in a broad range of disease areas. 

Our mission is to revolutionize disease treatment by inventing natural killer cell-based therapies for vastly improved patient outcomes. We believe in a small team with a big impact.

Apply for this job

*

indicates a required field

Resume/CV*

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter*

Accepted file types: pdf, doc, docx, txt, rtf

Education

Select...
Select...
Select...
Select...
Select...
Select...
Select...

When you apply to a job on this site, the personal data contained in your application will be collected by Dragonfly Therapeutics (“Controller”), which is headquartered at 180 3rd Avenue, Sixth Floor, Waltham, MA 02451 and can be contacted by emailing hr@dragonflytx.com. Controller’s data protection officer is MWB Consulting SARL, that can be contacted at dpo@mwbconsulting.com. Your personal data will be processed for the purposes of managing Controller’s recruitment related activities, which include setting up and conducting interviews and tests for applicants, evaluating and assessing the results thereto, and as is otherwise needed in the recruitment and hiring processes. Such processing is legally permissible under Art. 6(1)(f) of Regulation (EU) 2016/679 (General Data Protection Regulation) as necessary for the purposes of the legitimate interests pursued by the Controller, which are the solicitation, evaluation, and selection of applicants for employment.

Your personal data will be shared with Greenhouse Software, Inc., a cloud services provider located in the United States of America and engaged by Controller to help manage its recruitment and hiring process on Controller’s behalf. Accordingly, if you are located outside of the United States, your personal data will be transferred to the United States once you submit it through this site. Because the European Union Commission has determined that United States data privacy laws do not ensure an adequate level of protection for personal data collected from EU data subjects, the transfer will be subject to appropriate additional safeguards under standard contractual clauses. You can obtain a copy of the standard contractual clauses by contacting us at hr@dragonflytx.com.

Your personal data will be retained by Controller as long as Controller determines it is necessary to evaluate your application for employment. Under the GDPR, you have the right to request access to your personal data, to request that your personal data be rectified or erased, and to request that processing of your personal data be restricted. You also have to right to data portability. In addition, you may lodge a complaint with an EU supervisory authority.

Select...

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Dragonfly Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.