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Engineer, Downstream Process Development

Waltham, Massachusetts, United States

Engineer, Downstream Process Development

Dragonfly Therapeutics is seeking a downstream process development engineer to join our Tech Ops team (title commensurate with experience). This position will play a key role in collaborating with the R&D and Tech Ops teams to develop, optimize, and integrate cutting-edge processes and technologies for biologics process development. The individual will lead efforts to enhance current production methods, while also spearheading the development of innovative manufacturing processes. Responsibilities include developing production processes for tech transfer, evaluating new platform technologies, and troubleshooting technical challenges. We are looking for for an enthusiastic and innovative individual with a deep scientific interest in drug development, who thrives in a fast-paced, entrepreneurial environment. As such, the candidate must be goal-oriented, flexible, and able to work collaboratively across multiple projects with colleagues from research and development.

Responsibilities (including but not limited to):

  • Develop robust and scalable downstream processes to support Dragonfly’s novel multi-specific antibody and cytokine platforms ranging from chromatography to tangential flow and viral filtration
  • Design and improve processes related to protein recovery, scalability and purity
  • Run routine analytics including HPLC and capillary electrophoresis and analyze/summarize results
  • Prepare technical reports, SOPs, internal and external presentations
  • Identify, evaluate, and implement new and existing technologies to improve process efficiency, control, and understanding
  • Perform comprehensive data analysis (through excel or other statistical analysis software such as JMP), present data, conclusions, and recommendations to the broader team
  • Ensure effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks
  • Effectively maintain good communication and collaborate with cross-functional colleagues and external partners for successful execution/completion of projects
  • Prepare reagents, buffers, and equipment as needed to support experiments
  • Maintain Downstream PD laboratory to ensure consumables and raw materials are readily available and equipment is calibrated and properly maintained
  • This is a lab-based role. Additional duties and responsibilities will be assigned as required

Qualifications:

  • BS or MS degree in Chemical Engineering, Biochemical Engineering, Biochemistry or equivalent related fields with 5+ years of relevant industry experience, or PhD with 2 years, required
  • Strong hands-on experience in protein purification techniques such as filtration, chromatography, TFF, UF/DF, AKTA, UNICORN and HPLC systems. Experience with different modes of chromatography is required
  • Prior experience with biochemical characterization of proteins is required
  • Understanding of GxP activities such as reviewing GMP batch records, tech transfer reports, and campaign summary reports is desirable
  • Experience operating and programming high-throughput liquid handling platforms (e.g. TECAN, Hamilton, etc) is desirable
  • The candidate is self-motivated, accountable, inquisitive, and has excellent organization and communication skills

About Dragonfly

Dragonfly Therapeutics is a clinical-stage biopharmaceutical company committed to discovering, developing and commercializing therapies that use its novel multispecific antibody technology to harness the body's immune system to bring breakthrough treatments to patients. In addition to its wholly owned clinical assets, Dragonfly has a deep pipeline of wholly owned preclinical candidates discovered using its proprietary platform, as well as productive collaborations with Merck, AbbVie, Gilead and Bristol Myers Squibb in a broad range of disease areas. 

Our mission is to revolutionize disease treatment by inventing natural killer cell-based therapies for vastly improved patient outcomes. We believe in a small team with a big impact.

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