Bioinformatics Co-Op
Company Overview:
Dyne Therapeutics is focused on discovering and advancing innovative life-transforming therapeutics for people living with genetically driven neuromuscular diseases. Leveraging the modularity of its FORCE™ platform, Dyne is developing targeted therapeutics that deliver to muscle and the central nervous system (CNS). Dyne has a broad pipeline for neuromuscular diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD) and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. For more information, please visit https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.
Role Summary:
The Data Sciences team at Dyne Therapeutics is seeking a bioinformatics co-op student to participate in research on innovative oligonucleotide therapeutics for rare neuromuscular disease. You will apply your computational skills to the engineering and analysis of data in our drug discovery programs. In partnership with biologists and platform scientists, you will work with complex multi-omics and preclinical data sets. Through the use of data transformation and visualization methods, you will enable insights about novel therapeutic strategies and their impact on disease. Through the course of the co-op, you will gain a broad understanding of a variety of experimental and bioinformatics research methods in therapeutic discovery and development.
This role is based in Waltham, MA without the possibility of being remote This is a 6-month position beginning in July.
Primary Responsibilities Include:
- Implementation of foundation bioinformatics analytical pipelines for next gene sequencing, biological sequence searching/clustering, etc.
- Management, integration, and visualization of preclinical data
- Implementation of research computing environment with a commercial cloud provider
- Develop explainable machine learning models and deploy them as interactive dashboards
- Prepare presentation on:
- Software systems developed for research data management and analysis
- Clustering and visualization of muscle-selective peptide sequences from phage display libraries
- Visualization of preclinical data
Education and Skills Requirements:
- Undergraduate or Graduate student currently pursuing a degree in bioinformatics, applied mathematics, or computer science or equivalent experience
- Programming experience in R and/or Python; familiarity with code management and notebook IDE such as jupyter
- Understanding of relational databases, SQL, json, or other data management structures
- Strong organizational skills and solid written and oral communication ability
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The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.
This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.
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