Back to jobs

Senior Application Security Engineer

Remote, Washington, DC

We're looking for a seasoned Application Security Engineer to lead our security strategy from the ground up, ensuring we deliver safe, compliant, and robust software solutions. Keep reading to learn more about the role, our team, and why House Rx is the right next step in your career.

About The Role

We’re looking for a Senior Application Security Engineer to own application security from the ground up. This is a role with broad authority to architect, implement, and continuously improve how we build secure software. You won’t be “bolted on” to engineering - you’ll be embedded, trusted, and expected to lead.

Our core stack is TypeScript, Node.js, and AWS-native services. You will set the vision for secure development across our platform.

What You’ll Do

  • Build Our AppSec Program: Establish foundational security practices, policies, tooling, and enforcement mechanisms from the ground up.
  • Technical Leadership: Develop secure-by-default patterns and frameworks specifically for our TypeScript/Node.js codebase.
  • Security Reviews and Threat Modeling: Lead comprehensive threat modeling exercises, secure code reviews, and architecture assessments for platform services and product features.
  • Tooling & Automation: Select, deploy, and operationalize essential AppSec tools (e.g., SAST, SCA, secrets scanning, fuzzing) suitable for our current and future scale.
  • AWS Environment Hardening: Collaborate closely with engineering teams to enhance IAM controls, data encryption strategies, secure deployment pipelines, and logging mechanisms.
  • Secure Development Practices: Educate and mentor engineering teams through playbooks, checklists, training, and best practices.
  • Vulnerability Management: Lead vulnerability intake, triage, and remediation processes, providing clear guidance and tracking to resolution.
  • Incident Response: Serve as the Application Security SME during security incidents, partnering closely with IT and compliance teams to address issues rapidly and effectively.

About You

  • 5+ years of experience in application security or a strong engineering background with deep security expertise.
  • Expert-level proficiency with TypeScript, Node.js, and AWS (especially IAM, API Gateway, Lambda, EKS).
  • Hands-on experience selecting and managing security tooling (Semgrep, Snyk, CodeQL, etc.) with clearly articulated rationale.
  • A pragmatic approach to security - balancing robust protections with practical engineering constraints and rapid product development.
  • Strong communication skills and a passion for embedding security into engineering culture.
  • Bonus points for experience building security programs within regulated industries (healthtech, fintech, etc.).

In particular, we offer:

  • Flexible work hours and flexible paid time off
  • Generous parental leave
  • Comprehensive healthcare, vision and dental benefits
  • Competitive salary and equity stake

We’re backed by forward-thinking investors committed to transforming healthcare, including Bessemer Venture Partners, First Round Capital, LRV Health, Khosla Ventures, Maverick Ventures, 1984.vc, and Character.

While a cover letter is optional, a note sharing your enthusiasm for House Rx and this role is highly insightful.

Expected Full-Time Base Salary:  $150,000-$180,000

This range represents the low and high end of the anticipated base salary/wage. The actual base salary/wage will depend on several factors, including experience, knowledge, and skills. Actual compensation packages may include other elements equity, paid time off and benefits.

More About House Rx: Our Team, Work, and Culture

Here's our amazing PDE team that builds healthcare technology that matters:

  • Software Engineering: 10 engineers+ from early career to staff/architect level
  • Product & Design: 3 product managers, 2 designers
  • IT & Security: 3 IT Engineers, 1 Security Engineer
  • Infrastructure: 3 SREs
  • Quality & Support: 3 QA engineers, 2 support specialists

Together, we build and maintain impactful solutions through our pharmacy management system and data insights platform. These tools enable our internal teams, pharmacists, care coordinators, and clinical operations, to streamline medication access, while helping external healthcare providers and clinics deliver better patient care.

💻 Our engineering work presents exciting technical challenges as we balance user-facing features with robust internal systems. We release updates daily, requiring thoughtful prioritization and technical excellence while maintaining high quality. This iterative approach means we're constantly innovating to deliver meaningful improvements to our healthcare platform.

🌎 We're a fully remote team, with our talented people spread across New York, Boston, San Francisco, and throughout the U.S. While we embrace the flexibility of remote work, we're passionate about strengthening connections through our bi-annual retreats, both company-wide and PDE-specific, where we plan, grow, and celebrate our successes together. Local team members enjoy getting together for co-working and social events, creating bonds that go beyond the workplace.

🎉 Our culture brings thoughtfulness to our daily work. You'll find us expressing ourselves through our extensive Slack emoji and GIF collection (seriously, it's impressive!), sharing gratitude circles on birthdays, and having conversations that range from foodie recommendations to discussions about AI tooling, developer experience, and architecture. While we take our mission seriously, we believe enjoying what you do and technical excellence go hand in hand.

We're a fun, thoughtful, supportive, talented, and down-to-earth group focused on doing some of the best work of our lives. At the end of the day, we know software is built by people – and we're committed to taking care of both the people we work with and the patients whose lives we touch through our technology. We’re growing our team. There's no one else in the world like you, and hope you can join us for this ride! 🚀

 

 



Apply for this job

*

indicates a required field

Resume/CV*

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter

Accepted file types: pdf, doc, docx, txt, rtf

Select...
Select...

U.S. Standard Demographic Questions

We invite applicants to share their demographic background. If you choose to complete this survey, your responses may be used to identify areas of improvement in our hiring process.
Select...
Select...
Select...
Select...
Select...
Select...

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in House Rx’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.