Principal Scientist, Cancer Pharmacology, Translational Research

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

As a Principal Scientist in the Cancer Pharmacology team within the Translational Research group, in the Biomedical Discovery Research Department, you will:

• Provide scientific and strategic leadership for RAS(ON) inhibitor programs by translating mechanistic insights in RAS biology into impactful pharmacology strategies and translational study plans.

• Lead, mentor, and develop a high-performing group of in vivo scientists, fostering scientific excellence, innovation, and cross-functional collaboration.

• Drive the design, execution, and interpretation of in vivo efficacy and PK/PD studies conducted internally and through external partners to advance oncology discovery and development programs.

• Partner closely with the cross-functional quantitative modeling group to provide biological insight, translational context, and critical evaluation supporting PK/PD modeling efforts.

• Influence portfolio progression through generation of high-impact data packages and contributions to regulatory submissions.

• Serve as the in vivo pharmacology expert on cross-functional project teams, partnering closely with colleagues in Chemistry, Discovery Biology, DMPK, and Toxicology to build cohesive preclinical data sets.

• Communicate scientific strategy, key findings, and program recommendations to cross-functional teams and senior leadership to drive informed decision making.

Required Skills, Experience and Education:

• Ph.D. in Pharmacology or Cancer Biology, or a related scientific discipline with direct relevance to oncology drug development.

• 5+ years of relevant industry experience in oncology drug discovery and development.

• Demonstrated scientific leadership, strategic thinking, and problem-solving skills in advancing oncology drug discovery programs.

• Deep expertise in tumor biology, RAS signaling pathways, and translational oncology pharmacology.

• Extensive hands-on experience in the design, analysis, and interpretation of in vivo oncology studies and disease models.

• Strong understanding of translational PK/PD concepts and integration of efficacy, biomarker, and pharmacokinetic data to support translational hypotheses.

• Working knowledge of modeling approaches, including PBPK, QSP, and semi-mechanistic PK/PD frameworks.

• Proven track record of leading, mentoring, and developing scientific talent within collaborative, matrixed research environments.

• Excellent written and verbal communication skills with the ability to effectively communicate complex scientific concepts to both specialist and non-specialist audiences.

• Demonstrated track record of scientific innovation, productivity, and collaboration in a dynamic and fast-paced drug discovery environment.

Preferred Skills:

• Experience with RAS-targeted therapies and diverse oncology therapeutic modalities, including small molecules, antibodies, and antibody-drug conjugates (ADCs).

• Strong theoretical understanding of the concepts, assumptions, and limitations associated with PK/PD and translational mathematical modeling.

• Experience contributing to IND-enabling activities and regulatory documentation is desirable.

• Demonstrated ability to influence scientific strategy and effectively operate within highly collaborative cross-functional teams.

#LI-Hybrid   #LI-NE1

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