Associate Director / Director, Technology Services

About Stoke:

Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit https://www.stoketherapeutics.com/

Position Purpose: 

Stoke is seeking a hands-on Associate Director / Director, Technology Services to lead day-to-day IT operations: help desk, end-user computing, desktop and field support, infrastructure and networking, collaboration and audio/visual technology, laboratory IT infrastructure, and the technology for Stoke’s new Waltham headquarters. This leader will lead IT’s part in the company’s move to Waltham in December 2026 / January 2027 (the start date is intended to coincide with the move), and build a support model that scales with a growing field organization. Technology Services exists to keep every Stoke function running; its success is measured by the experience of the people it supports. The role leads the Technology Services pillar of IT, is a member of the IT leadership team, and reports to the SVP & Chief Information Officer. 

Key Responsibilities: 

• Lead and develop the Technology Services team (help desk manager, systems administration, help desk staff and contractors), setting service standards, SLAs and the on-site support model. 

• Own infrastructure and end-user technology: network and Wi-Fi, identity and endpoint management, Microsoft 365 and collaboration tools, conference rooms and AV, printing, mobile devices, cloud infrastructure, and backup and disaster recovery. 

• Deliver IT for the Waltham move in partnership with Facilities & Engineering: network, Wi-Fi and AV build, access control and building systems integration, cutover planning, day-one support and decommissioning of the Bedford site. 

• Own laboratory IT infrastructure: instrument connectivity, lab network segmentation and lab endpoint support, in coordination with Facilities and the Scientific Applications lead (who owns research applications). 

• Deliver field force readiness ahead of launch for Sales & Marketing and Field Medical: device provisioning and mobile device management (Intune/Autopilot), remote onboarding, field support hours and self-service, scaled to the 2027 hiring plan. 

• Serve as the operational counterpart to Information Security and the MDR provider: execute endpoint protection, patching and access provisioning to the standards Security defines; triage and remediate infrastructure and endpoint findings; and own tracking of remediation from external security assessments and audits through to closure, with ITGC evidence maintained alongside. 

• Partner with Information Security on operational IT policies and standards (acceptable use, asset lifecycle, backup and disaster recovery, endpoint and access provisioning procedures), keeping them current, documented and audit-ready; ensure resilience and no single points of failure across operations. 

• Deploy, provision and support enterprise AI productivity tools for end users, including configuration, access and staff enablement, within the governance set by the CIO’s Data & AI function and Information Security. 

• Support infrastructure qualification and controls for GxP and SOX-relevant systems with the Clinical & Regulatory Systems and Enterprise Applications teams. 

• Manage vendors and managed service providers, contracts, hardware and software lifecycle, asset inventory and the Technology Services budget. 

• Run incident, problem and change management; define and report operational metrics and service levels. 
• Contribute to IT strategy and standards as a member of the IT leadership team. 

Required Skills & Experience:  

• Bachelor’s degree in computer science, information systems or a related field, or equivalent experience. 

• 10+ years of progressive IT operations and infrastructure experience in biotech, healthcare or managed-services environments, including experience leading an IT team or function. 

• Strong hands-on background in Microsoft 365, Entra ID (Azure AD), Intune or equivalent endpoint management for Windows and macOS, networking (switching, Wi-Fi, firewalls) and cloud infrastructure. 

• Experience with office build-outs, relocations or comparable infrastructure projects, including network and AV. 

• ITIL-based service management experience; has built SLAs and support models for a distributed workforce. 

• Experience operating in a regulated environment, including SOX IT general controls and GxP infrastructure qualification, and working with an MDR/SOC provider and external security assessments. 

• Vendor and managed service provider management and budgeting experience. 
• Service-minded, calm under pressure, and an excellent communicator with technical and non-technical colleagues. 

Preferred Skills & Experience: 

• ITIL, Microsoft, Cisco/Meraki or comparable certifications. 

• Experience supporting a commercial field team or product launch, and with laboratory IT and scientific instrument connectivity. 
• Experience rolling out and supporting enterprise AI productivity tools (for example Microsoft Copilot or Claude) for end users. 

Culture & Values: 

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. 

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.   

Location(s):  

Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This position is an on-site position with work-from-home flexibility, currently based in Bedford and will later be based in Waltham.  

Travel: 

This position will require approximately 5% travel.  

Compensation & Benefits: 

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.  

The anticipated salary range for this role at the Associate Director level is $160,000 - $200,000 and at the Director level is $200,000 - $240,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation. 

Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).  

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do. 

Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:

https://www.stoketherapeutics.com/careers/

For more information, visit https://www.stoketherapeutics.com/.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.