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Principal Scientist, DMPK

Boston, MA

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45 and 50 skipping amenable. We have also partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You are a highly motivated, collaborative, and innovative Drug Metabolism and Pharmacokinetics expert with experience driving preclinical DMPK activities. We have a diverse pipeline and as such you should have experience across both small and large molecules and have hands on experience leading the design, analysis, and interpretation of preclinical in vitro and in vivo studies. You are an exceptional communicator and a natural collaborator who is excited about the opportunity to contribute to this function and work closely with cross functional leaders.

The Opportunity

The ideal candidate will serve as a subject matter expert working within the DMPK team to drive the DMPK strategy across all designated programs and pipelines. They will have the opportunity to design, manage, and execute DMPK deliverables, and will be responsible for analyzing, interpreting, and authoring/reviewing ADME and PK/PD reports.

Responsibilities

  • Lead all PK- and ADME-related efforts for designated program(s).
  • Communicate and present relevant information across all areas of the organization, regardless of level.
  • Select and manage PK/TK, PK/PD, and ADME CROs.
  • Author and review PK/TK, PK/PD, and ADME reports.
  • Author and review relevant PK/TK, PK/PD, and ADME sections of regulatory submission documents (e.g. investigational new drug (IND), investigator brochure (IB), clinical trial application (CTA), etc)
  • Review associated reports, including clinical, toxicology, pharmacology, and bioanalysis.
  • Collaborate with clinical teams, including pharmacology, biomarkers, development, and operations.
  • Collaborate with non-clinical development teams, including toxicology and bioanalysis.
  • Collaborate with discovery teams to guide future programs and better understand mechanisms of action.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

  • Humanity - We genuinely care about patients and about one another.
  • Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
  • Creativity - We are creative problem solvers.
  • Collaboration - We are more than the sum of our parts.
  • Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

  • PhD in pharmacology or similar field with 8+ years of DMPK experience in an industry setting or a MS with 12+ years of relevant experience.
  • Expertise with ADME studies and assays, with a proven track record of strategizing and troubleshooting based upon raw data.
  • Vendor Management experience, specifically managing CROs.
  • Additional experience with other aspects of ADME, bioanalytical techniques, PK/PD, toxicokinetics, pre-clinical PK/PD modeling, and translational biology are strongly preferred.
  • Experience with oligonucleotide-based modalities.
  • Experience authoring and reviewing DMPK-related reports and regulatory documents for health authority submissions is highly desirable.
  • You should be naturally collaborative and a strong communicator, and let’s not forget the ability to multi-task effectively and work within aggressive timelines– these are key to being successful in Entrada’s fast paced environment.
  • This is a US based remote position, with preference given to local New England based candidates. This role will require minimum quarterly travel to the Entrada Therapeutics Headquarters located in Boston, MA. #LI-Remote #LI-CZ1

The Perks

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

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Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

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