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Executive Director, Program & Portfolio Management

Boston, MA

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45 and 50 skipping amenable. We have also partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You operate independently, live in the details and are able to identify and analyze risk while seamlessly pivoting to meet evolving program and portfolio-level priorities in a fast-paced environment. You are proactive, you follow up and follow through, connecting problems with solutions with efficiency.  You are the kind of team member people seek out for partnership and problem solving, and you have a demonstrated track-record of driving cross-functional planning for multiple programs, with the strong interpersonal skills to effectively build collaborative working relationships. 

The Opportunity

The Executive Director of Portfolio Management will play an integral role in working with cross-functional leaders to evaluate forward-looking risks and opportunities across a portfolio containing multiple development programs.  We are looking for an Executive Director who is a strategic thinker, experienced, flexible, disciplined, proactive, and collaborative

Responsibilities

  • Partner with Portfolio team members as well as cross-functional team members on proactive identification of near/mid/long-term risks to individual programs as well as to the broader portfolio.
  • Lead portfolio-level scenario identification and planning (and support program-level scenario planning as relevant from a portfolio lens).
  • Use scenario analysis to help inform long-term strategic planning, resource allocation, and organizational / workforce planning.
  • Develop and implement ongoing portfolio-level analysis and visualization tools.
  • Develop and implement ongoing portfolio-level risk tracking and impact assessment.
  • Work with program management to proactively identify and monitor key risks/opportunities, relevant considerations for decision making, and support in creating forums for the presentation of key information and timely decision making and communication.
  • Work with program management to establish and standardize integrated development planning at all stages of project/program development.
  • Summarize complex topics to facilitate cross-functional team discussions and decision making, and relay information regarding status, issues, decisions, etc. to senior leadership as appropriate.
  • Drive aligned decision-making through proactive identification and escalation of critical issues and implications.
  • Interact with additional functions (e.g., finance, strategy, communications, legal, and operations) as needed to ensure transparency and alignment.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

  • Humanity - We genuinely care about patients and about one another.
  • Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
  • Creativity - We are creative problem solvers.
  • Collaboration - We are more than the sum of our parts.
  • Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

  • BS/BA degree required, MS/MBA/PhD preferred.
  • PMP certification preferred.
  • Experience in supporting drug development within the pharmaceutical/biotech industry.
  • 15+ of experience managing cross-functional teams in preclinical and clinical stages of development.
  • High level of mastery in biotech program and portfolio management.
  • Ability to quickly identify and implement “fit-for purpose” processes to support cross-functional team planning.
  • Demonstrated success guiding teams through key submission milestones (e.g., IND / CTA, NDA / BLA, etc), including goal setting, planning, timeline management, and transition through stage gates.
  • Leadership skills, personal integrity and the ability to work well within a team in a fast-paced environment is critical.
  • Strong oral and written communication skills.
  • Good skills with Microsoft Project, Excel, PowerPoint and Word.
  • This is a US based remote position, with preference given to local New England based candidates. This role will require minimum quarterly travel to the Entrada Therapeutics Headquarters located in Boston, MA. #LI-Remote

The Perks

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

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Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

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