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Senior Research Associate, Ocular Research (CONTRACT)

Boston, MA

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45 and 50 skipping amenable. We have also partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You are a versatile, self-motivated, and eager Research Associate who is looking forward to rolling up your sleeves and contributing to all aspects of the ocular pipeline here at Entrada. You look forward to supporting efforts for testing EEV, antisense oligonucleotides, and small interfering ribonucleic acids in vitro and in vivo. You are ready to partner with drug discovery scientists as we evaluate gene targeting modalities and carry out analytical assays for functional validation both in vitro and in vivo. 

The Opportunity

The Senior Research Associate, Ocular Research (Contract) will have the opportunity to be involved in several aspects of Ocular programs, including assisting in developing in vitro diseased models using iPSCs. You’ll be expected to work through techniques like RNA/DNA extraction, RT-PCR, RT-qPCR, RT-ddPCR, western blot, tissue embedding, sectioning, staining, and imaging. The ideal candidate will be managing and ordering chemicals and supplies, as well as writing protocols. They will be an integral part of the Ocular team, supporting the development and expansion of Entrada’s Ocular portfolio. 

Responsibilities

  • Maintain and culture iPSCs and 3D retinal organoids differentiation to support the ocular team.
  • Process samples for histological analysis by performing fixation, OCT embedding, sectioning, immunofluorescence staining and imaging.
  • Assist and conduct experiments utilizing molecular techniques (DNA/RNA extraction, RT-qPCR, ddPCR, and western blot).
  • Develop and execute cell-based or ex-vivo assays for validating biological activity of oligonucleotide therapeutics. 
  • Prepare SOPs, present data and research findings at internal meetings.
  • Collaborate with cross-functional Discovery Teams to advance the pipeline and contribute to the completion of corporate goals.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

  • Humanity - We genuinely care about patients and about one another.
  • Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
  • Creativity - We are creative problem solvers.
  • Collaboration - We are more than the sum of our parts.
  • Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

  • BS with 2-4 years or MS with 2+ years of relevant experience.
  • Experience with iPSC cell culture, maintenance and differentiation of retinal organoids.
  • Experience in the ocular space is strongly preferred.
  • Hands-on experience with in vitro assays including PCR, ddPCR, qPCR, Western blotting, and immunostaining is highly desirable.
  • Organized and focused on moving projects forward.
  • Desire to work in an innovative and collaborative environment pursuing high reward science.
  • Ability to juggle and prioritize multiple responsibilities, projects, and timelines. 

The Perks

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

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Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

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