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Executive Director, Clinical Business Operations

Boston, MA

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45 and 50 skipping amenable. We have also partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You are a seasoned leader in the pharmaceutical industry who is eager to shape and implement business operations strategies for clinical trials. You are well organized and collaborative, able to work seamlessly with teams to drive our clinical activities. You thrive in a fast-paced environment, juggling priorities, and stepping in wherever needed. With a proven track record in scaling operations within biotech or pharmaceutical settings, you are a results-driven problem solver who efficiently connects problems with solutions. Your strong interpersonal skills enable you to build effective relationships inside and outside the company. If you're passionate about making a difference and driving results, we want to hear from you!

The Opportunity

The Executive Director, Clinical Business Operations, is a strategic leadership role within the R&D organization, dedicated to driving operational excellence across clinical operations, statistics, and data management. This role focuses on designing and optimizing business processes to ensure regulatory compliance, operational efficiency, and scalability to support the company’s growth.  With oversight spanning clinical compliance, technology systems, and vendor partnerships, the Executive Director will play a key role in shaping the company's clinical trial operations and building capabilities to meet future portfolio demands.

Responsibilities

  • Lead Entrada’s clinical trial business operations strategy and execution for the organization's entire portfolio, ensuring alignment with long-term business and R&D objectives.
  • Collaborate with cross-functional leaders to proactively develop fit-for-purpose strategies and scalable processes and solutions that enable consistent, timely and efficient delivery of the portfolio. This includes the operational and technology roadmaps for clinical operations, data management and statistics, aligning with organizational goals.
  • Guide organizational alignment through clear communication of clinical portfolio progress, risks, and strategic priorities to executive leadership, fostering transparency and accountability.
  • Oversee the selection, implementation, and management of key clinical technologies (e.g., TMF, EDC, statistical tools), ensuring compliance with regulatory requirements and integration into portfolio-level study execution.
  • Cultivate and maintain strategic partnerships with Contract Research Organizations (CROs) and other vendors to optimize timelines, budgets, and quality across the portfolio.
  • Recruit, develop, and retain top talent, fostering a collaborative and high-performing team culture.
  • Partner with functional leaders in finance, legal, operations, and regulatory affairs to drive alignment across the clinical trial portfolio, ensuring strategic priorities are consistently met.
  • Drive a culture of innovation and operational excellence, ensuring the clinical operations function remains at the forefront of industry best practices and emerging trends.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

  • Humanity - We genuinely care about patients and about one another.
  • Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
  • Creativity - We are creative problem solvers.
  • Collaboration - We are more than the sum of our parts.
  • Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

  • Bachelor’s degree in life sciences, business, or a related field; advanced degree preferred.
  • 15+ years of progressive leadership experience in clinical operations or related areas, including building and managing high-performing teams.
  • Deep understanding of clinical trial processes, vendor management, and regulatory requirements (e.g., ICH-GCP, 21 CFR Part 11).
  • Proven experience selecting and managing CROs, vendors, and clinical trial consultants.
  • Strong project management skills and the ability to lead cross-functional teams in a matrixed environment.
  • Experience with technology implementation and operational transformation within clinical trials.
  • Demonstrated success in scaling operations within a fast-paced, entrepreneurial biotech or pharmaceutical setting.
  • Strong analytical skills with the ability to synthesize complex data and communicate actionable insights.

The Perks

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

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Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

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