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Principal Scientist, Pharmacometrics

Boston, MA

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

We are looking for someone who is enthusiastic about modeling and the big picture of drug development. You are passionate about joining a growing organization where your knowledge and experience are highly valued. You thrive in a collaborative environment, working with others to enhance infrastructure throughout the organization. You follow up and follow through, efficiently connecting problems with solutions.

The Opportunity

We are seeking a dynamic and motivated Principal Scientist, Pharmacometrics who will bring extensive expertise in quantitative pharmacology. The ideal candidate will have a strong background in the applications of model-based drug development within the biotechnology or pharmaceutical industry and be passionate about translating science into approved and accessible medicines. You will report directly to the Head of Clinical Pharmacology and partner closely with various functions of our growing organization.

Responsibilities

  • Use modeling approaches to advance clinical and translational research at Entrada Therapeutics.
  • Lead cross-functional teams with scientific acumen to develop and execute. pharmacometrics for programs across all phases of drug development.
  • Support the development of diverse modeling strategies and execution, in collaboration with the Head of Clinical Pharmacology, to bring value to the Entrada portfolio.
  • Work collaboratively with functional partners, including Clinical Development, Biostatistics, Non-Clinical Product Development, Clinical Operations, and Regulatory to deliver on both project team and corporate objectives.
  • Author regulatory documents including analysis plans, study reports, population PK reports, exposure-response analyses reports and other similar documents.
  • Monitor work with CROs and other external vendors to ensure compliance with agreed protocols, quality standards, and timelines.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

  • Humanity - We genuinely care about patients and about one another.
  • Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
  • Creativity - We are creative problem solvers.
  • Collaboration - We are more than the sum of our parts.
  • Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

  • Ph.D. in pharmaceutical sciences, pharmacology, pharmacometrics, pharmacokinetics, or related discipline or Pharm.D. or M.D. with relevant experience.
  • 4+ years’ experience with background in the application of mathematical, pharmacokinetics, and statistical methods within pharma/biotech industries or drug development.
  • Experience using Phoenix WinNonlin, R, NONMEM, MATLAB, or other pharmacokinetic and modeling software.
  • Strong mathematical model development and analytical skills.
  • Proficient documentation and organizational skills, as well as proven ability to be self-motivated and able to work independently.
  • Excellent communication and presentation skills to efficiently relay information to project teams and other key stakeholders.
  • Ability to travel approximately 15% of the time, as determined by the needs of the business.
  • This is a US based remote position, with preference given to local New England based candidates. This role will require minimum monthly or quarterly travel to the Entrada Therapeutics Headquarters located in Boston, MA. #LI-JF1 #LI-Remote

The Perks

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

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