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Manager, Early Innovation & Scientific Strategy

Boston, MA

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. 

Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA- and protein-based programs for the potential treatment of neuromuscular and ocular diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You are interested in working at the intersection of life sciences and business. You thrive in figuring out the details and understanding the nuances while still making connections to the bigger picture. You look forward to working with and learning from leaders across the organization in a high impact role.

The Opportunity

The Manager, Early Innovation & Scientific Strategy will play a critical role in shaping Entrada’s early-stage pipeline by supporting strategic assessment of new indications, gathering external insights, and translating emerging scientific data into actionable development recommendations. This individual will roll into the Business Development unit, and report to the Director of Strategic Alliances and Portfolio Innovation. You will work with cross-functionally with internal teams including scientific strategy, competitive intelligence, R&D scientific teams, and external experts. You are a creative problem solver who brings clarity and strategic thinking to complex scientific and business questions.

Responsibilities

Indication Assessment & Strategic Analysis

  • Conduct structured evaluations of potential new indications, including disease biology, patient populations, unmet needs, standard of care, competitive landscape, and therapeutic rationale.
  • Develop indication scoring frameworks or decision models to inform program prioritization with R&D and business leadership.
  • Translate scientific concepts into clear strategic implications for pipeline fit and development paths.

External Insights & KOL Engagement

  • Identify, engage, and maintain relationships with Key Opinion Leaders (KOLs), academic experts, and clinical investigators to inform program hypotheses and development strategy.
  • Prepare background materials, discussion guides, and summaries from KOL interactions to guide internal strategic discussions.
  • Monitor evolving scientific and clinical trends relevant to target indications or modalities.

Data Synthesis & Strategic Recommendations

  • Analyze internal experimental data, translational findings, and preclinical results to identify development opportunities, gaps, or next-step experiments.
  • Develop clear, actionable recommendations for program progression, experimental design, or alliance strategy.
  • Support creation of strategic narratives, including target product profiles (TPPs), development roadmaps, and go/no-go frameworks.

Cross-Functional Collaboration

  • Work closely with Discovery Research, Program Management, and Business Development to develop integrated early program plans.
  • Support preparation of materials for internal governance, external collaborators, and Executive Leadership.
  • Ensure early strategy work is aligned with broader company goals and partnership commitments

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

  • Humanity - We genuinely care about patients and about one another.
  • Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
  • Creativity - We are creative problem solvers.
  • Collaboration - We are more than the sum of our parts.
  • Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

  • Advanced degree in life sciences (PhD, MS, or equivalent) required, biology & physiology (or similar) focus preferred.
  • 3+ years of experience in biotech/pharma in roles such as program strategy, competitive intelligence, translational science, or management consulting with a life sciences focus.
  • Strong scientific literacy with the ability to interpret preclinical and translational data.
  • Experience interacting with external experts or KOLs is strongly preferred.
  • Experience conducting indication assessments and/or evaluating disease biology.
  • Excellent communication skills and ability to synthesize complex information into clear, structured recommendations.
  • Ability to work independently, manage multiple workstreams, and collaborate effectively in a cross-functional environment.
  • This role follows a hybrid working model, with office attendance 2-3 days per week minimum at the Entrada Therapeutics Headquarters in Boston, MA.

What We Offer: Meaningful Work, Fair Rewards, and Real Support

At Entrada Therapeutics, we understand that compensation and total rewards are a major consideration when exploring a new opportunity. We believe in transparency and equity and are committed to sharing salary ranges for every position, along with insight into our compensation philosophy, in accordance with certain state requirements in the United States and fostering a fair and open environment at the onset.

But we also know it is more than just pay. When you join Entrada, you’ll be part of a mission-driven team with access to comprehensive health, dental and vision coverage; life and disability insurance; with a 401(k) match. We pride ourselves on offering competitive benefits that empower our employees and reflect the value of their contributions – offering paid, gender-inclusive parental leave, holistic support for your health and well-being, education reimbursement, discretionary time off and commuting benefits aligned to your working model. If you find yourself working from our office in Boston’s Seaport District, this puts you steps away from some of the best the city has to offer.

“Our approach to compensation is grounded in transparency, equity and performance for the unique contributions each person brings. At Entrada, we know that meaningful work deserves meaningful reward — and we view compensation as one way we show appreciation for the collaboration, curiosity and commitment that drive our mission forward.”

— Kerry Robert, SVP of People

The salary for this opportunity ranges from $152,000 - $190,000. The final base compensation offered will depend on several considerations which include but may not be limited to a candidate’s skills, competencies, experience and other job-related factors permitted by law. The final salary offered may fall outside of this range. #LI-GG1 #LI-Hybrid 

Equal Opportunity Employer

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law. 

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Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

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