In Vivo Pharmacology Co-Op

Ampersand Biomedicines is an innovative, privately held biotechnology company leading the way in developing multi-specific medicines that direct a wide range of therapeutic molecules to specific cells and biological contexts (www.Ampersand.bio). Ampersand was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created. With a strong emphasis on innovation, Ampersand cultivates a highly dynamic and entrepreneurial environment.

Position Summary:

Ampersand is seeking a highly motivated and enthusiastic co-op to join our in vivo team and contribute to our in vivo and ex vivo studies involving antibodies and related biological molecules. This is an exciting opportunity to be part of the development of the next generation of biologics within a dynamic and entrepreneurial environment.

The successful candidate will work with his/her supervisor to design, plan, and conduct molecular biology and in vivo and ex vivo experiments to investigate the pharmacokinetics (PK), pharmacodynamics (PD), and efficacy function of our proprietary therapeutics. The successful candidate will work both independently as well as part of the team to achieve group objectives. The candidate will have the opportunity to develop a diverse skill set in molecular biology as well as in vivo and ex vivo assays. Through this experience, he or she will gain knowledge of antibody production platforms and optimization strategies as well as an introduction to the general drug development process in an industrial setting.

Key Responsibilities

• Work with the supervisor to plan, design, and execute experiments, analyze data, and interpret experimental results.
• Assist in surgical procedures, including dissections and collection of organs.
• Provide support for ex vivo studies to characterize the efficacy of antibodies and other molecules following in vivo experiments.
• Conduct molecular biology assays such as RNA and protein preparation, real-time PCR, ELISA, flow cytometry, and western blot, et al.
• Maintain accurate and thorough written records of laboratory procedures, results, and conclusions.

Preferred Qualifications 

• Bachelor’s or master’s degree in biology, pharmacology, or a related field.
• Experience with molecular biology techniques, such as RNA and protein preparation, real-time PCR, ELISA preferred.
• Experience with basic animal husbandry, handling, and dosing by multiple routes (IV, IP, PO, IM, etc.), or a desire to learn these techniques
• Experience in blood collection (Saphenous vein, cardiac blood collection), anesthesia administration, surgical procedures, dissection techniques, and tissue collection.
• Highly motivated and a strong team player, thriving in a fast-paced, inclusive, team-oriented, and multidisciplinary environment typically found in small biotech companies.
• Good organizational skills.
• Ability to use basic Microsoft office software such as Excel and PowerPoint.

About Flagship

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.