Scientist / Senior Scientist, Molecular Biology, Contractor

Cambridge, MA

Generation Bio is a biotechnology company changing what is possible for people living with T cell-driven autoimmune diseases. The company is developing novel therapeutics leveraging its T cell selective cell-targeted lipid nanoparticle (ctLNP) to deliver siRNA in vivo, enabling modulation of T cell activity that causes inflammation and auto-reactive tissue destruction. By selectively modulating T cells that drive disease pathology, ctLNP-siRNA therapeutics could potently block target function with sequence-level specificity while sparing the broader immune system. This potent new modality is designed to reach targets that are poorly drugged by other approaches, opening a broad indication space of T cell driven autoimmune diseases.

We are a thriving, collaborative, creative community of 100 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.  

Delve further.  Please visit www.generationbio.com or follow @generationbio. To see additional roles, please also check out https://generationbio.com/careers/ 

SUMMARY:

Generation Bio is seeking an energetic and motivated Scientist to join our molecular biology team. The scientist will primarily be responsible for developing and implementing high throughput cell assays for the purpose of characterizing the performance of siRNA candidates. The successful candidate will apply a range of assay endpoints, including expression knock down, siRNA stability and RISC-loading efficiency to determine siRNA performance. More generally, the scientist will contribute to the iterative design and evaluation of siRNA molecules to drive program and platform development. The position is cross-functional, requiring collaboration with Bioinformatics, Formulation and Preclinical teams.

 

RESPONSIBILITIES: 

  • Develop and implement high-throughput cell assays to characterize the performance of siRNA candidates
  • Develop and apply a range of assay endpoints including expression knock down, siRNA stability and RISC-loading
  • Contribute to iterative design and evaluation of siRNA molecules to drive program and platform development
  • Collaborate with pre-clinical teams to develop therapeutic molecules based on program needs
  • Work independently to execute experiments on time to meet company goals
  • Present scientific ideas and results effectively to different teams and groups within the organization

 

QUALIFICATIONS:

  • PhD in Molecular Biology, Cell Biology, Synthetic biology, Bioengineering, Biochemistry or related discipline.
  • Minimum of 2 years of relevant experience post PhD
  • Experience with high-throughput cell assay development and implementation is required
  • Experience with molecular endpoints relevant to nucleic acid therapeutic modalities (E.g. Expression, stability, on vs off target) is required
  • Expertise in tissue culture demonstrated across a range of cell lines is required
  • Experience applying high throughput assays to candidate screening and optimization is highly desired
  • Capacity for innovative thinking and critical problem solving
  • Excellent communication and interpersonal skills with capacity and proven track record of working cross functionally

 

POSITION: 6 month contract

 

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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