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Director of Engineering, Clinical Genomics (Remote, US-based)

Remote

Our Company

Genomenon is an AI-driven biomedical intelligence company on a mission to save and improve lives by making biomedical information actionable. Rare diseases affect more than 30 million people in the U.S. alone and hundreds of millions globally,  yet most patients still face long diagnostic journeys and limited treatment options.

Our goal is clear and ambitious: to deliver the information that shapes diagnosis and treatment for every rare disease patient.

We turn vast, complex biomedical data — spanning genomics, clinical evidence, and scientific literature — into trusted intelligence that helps clinicians diagnose patients, enables researchers to make new discoveries, and supports life sciences organizations in bringing better therapies to market faster.

Our work has real, measurable impact. Genomenon’s platforms and services are used by hundreds of clinical laboratories, healthcare organizations, and life sciences teams and pharma companies to support diagnostic interpretation, variant curation, and evidence-based decision-making and drug development. Each year, our technology helps inform care for tens of thousands of patients facing rare, complex, and time-sensitive conditions, reducing uncertainty and delivering answers when they matter most.

What makes Genomenon unique is our ability to support both clinical diagnostics and pharmaceutical innovation on a shared foundation of advanced AI, deep domain expertise, and rigorously curated data.

  • In the clinic, our solutions directly influence real-world patient outcomes.
  • In pharma, we enable teams to harness literature-derived real-world evidence across discovery, development, and regulatory workflows — turning fragmented biomedical knowledge into a strategic asset.

If you’re motivated by impact, energized by complexity, and excited to help shape the future of rare disease diagnosis and treatment, there’s no better place to do that work.

Genomenon /ge.gno.mai.non/
Source language: ancient Greek

  1. Verb
    to come into being
    to be born out of need
  2. Noun
    the leader in genomic intelligence

Our Community

Genomenon team members are thoughtful, ambitious, and mission-driven professionals working across states and countries. Our team brings together scientists, clinicians, engineers, and commercial leaders who collaborate as equals and learn from one another every day.

We value curiosity, accountability, and people who thrive in fast-moving, high-impact environments.

We are guided by our core values:

  • Always Learning: Approach challenges with curiosity and a growth mindset
  • Data-Driven: Ask a lot of questions and look to the evidence for answers
  • Humbly Confident: Aware of the value that we and others bring to the team 
  • Customer & Patient Driven: Put patients and customers first in everything we do
  • True Grit:  Embody passion and persistence, and aren’t afraid of hard work

Director of Software Engineering, Clinical Genetics

Genomenon is an AI-driven genomics company. Our mission is to save and improve lives by making genomic information actionable. We organize the world’s genomic knowledge and put it at the fingertips of clinicians and scientists to help diagnose and treat patients suffering from rare diseases and cancer.

Our flagship product, Mastermind, is a genomics intelligence platform that connects patient DNA to the scientific literature, accelerating clinical interpretation and precision medicine. We’re modernizing our commercial and internal software platforms to leverage AI-derived data, scalable APIs, and cloud-native architectures that support both customer-facing applications and internal clinical curation workflows.

This role is software engineering first. While it includes mentoring and light people management, the primary expectation is that you actively design, build, and ship production software. This position is best suited for an experienced, hands-on full stack engineer who enjoys leading by example and staying deeply engaged in day-to-day coding.

Position Responsibilities

  • Lead the hands-on technical development of Genomenon’s clinical genetics software, including commercial applications (UI, APIs, and data deliverables) and internal tools supporting genetic curation
  • Act as a senior individual contributor and technical lead, spending a significant portion of time writing, reviewing, and shipping production code
  • Serve as the technical lead partner to Product, collaborating on strategic vision, functional requirements, roadmap definition, and sprint planning
  • Manage and mentor a small, high-impact engineering team (approximately 3 developers), with a focus on technical growth, code quality, and delivery rather than people administration
  • Design, implement, and review performant, maintainable user interfaces with a strong emphasis on modern UI engineering using React
  • Build and maintain backend services and APIs using Python and GO, supporting both user-facing applications and downstream data workflows
  • Develop and maintain CLI scripts, internal tools, and lightweight automation workflows to support engineering, data, and clinical operations
  • Contribute to system architecture and design decisions as platforms evolve to incorporate AI-derived data, new APIs, and scalable backend services
  • Establish and reinforce best practices around code quality, testing, documentation, and operational reliability across frontend and backend systems
  • Balance near-term delivery with long-term technical strategy, proactively identifying opportunities to reduce technical debt and improve scalability
  • Collaborate closely with data science, clinical curation, DevOps, and product stakeholders to ensure solutions are robust, practical, and well understood

About You

You are a senior, hands-on software engineer who enjoys building real products and leading through technical contribution. You have recent, meaningful experience writing production code and do not see management as a replacement for engineering, but as a complement to it.

You are comfortable moving between UI development, backend services, scripting, and automation, and you enjoy owning problems end to end. You communicate clearly, mentor thoughtfully, and enjoy translating complex technical systems into tools that support clinicians, scientists, and patients.

You are excited to modernize established software platforms, adopt AI-driven capabilities, and help define the next phase of clinical genetics software through direct technical leadership.

Skills and Background

  • Bachelor’s degree in computer science, software engineering, or a related field; advanced degrees are a plus
  • 8+ years of professional software engineering experience, with recent, hands-on development as a core part of your role
  • Demonstrated experience as a full stack engineer, with strong depth in frontend development and solid backend expertise
  • Strong UI engineering foundation, including extensive experience building modern web applications with React and related frontend technologies
  • Proficiency in Python and GO for API development, business logic, and data integration
  • Experience writing CLI tools, scripts, and basic automation workflows to improve developer productivity and operational efficiency
  • Experience building and supporting API-driven systems that serve UI applications and downstream data consumers
  • Solid understanding of data modeling, schema design, and complex domain-driven systems
  • Prior experience mentoring engineers or acting as a tech lead, with limited but meaningful people management responsibilities
  • Strong system design skills, with experience evolving or modernizing existing software platforms
  • Excellent communication and collaboration skills, with comfort working closely with Product and cross-functional stakeholders
  • Commitment to writing high-quality, well-tested, maintainable software

Nice to Haves

  • Experience working with bioinformatics, genomics, or clinical data systems
  • Familiarity with basic genetics concepts and clinical interpretation workflows
  • Experience integrating AI-derived or ML-adjacent systems into production software
  • Experience modernizing or scaling SaaS platforms in regulated or high-impact domains

Our Commitment

Building a great company starts with building a diverse and inclusive team. We believe that people with different backgrounds, perspectives, and life experiences help us solve harder problems and build better solutions.

Genomenon is committed to inclusion across race, gender, age, religion, identity, disability, and background — in how we hire, how we work, and how we lead.

If you’re excited about the role but unsure whether you meet every qualification, we encourage you to apply. We’d rather review one more resume than miss the chance to meet someone exceptional.

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