Senior/Staff Scientist, Surface Chemistry

About Glyphic:

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What we are looking for in you

We are seeking a highly skilled and experienced Surface Chemist who will be responsible for developing solid-phase supports for DNA synthesis and protein sequencing via Glyphic’s proprietary technology. This role reports to the Director of Chemistry and requires expertise in surface chemistry, solid-phase synthesis, and analytical techniques. The successful candidate will work independently in a laboratory environment and collaborate effectively with cross-functional teams.  This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.

What you’ll do

• Develop solid supports that meet the physicochemical performance requirements for a novel single molecule protein sequencing workflow and will be compatible with automation equipment.
• Source and synthesize custom supports to investigate surface functionalization, porosity, size, stability, and manufacturability.
• Optimize functionalization chemistries (includes covalent, cleavable, linkers, passivation) to improve interfacial reaction kinetics and efficiency and assay signal-to-noise.
• Develop and validate analytical methods to characterize/QC solid supports.
• Develop and validate functional testing methods to characterize/QC solid supports.
• Partner with scientists and engineers to deploy novel supports into SOP workflows.
• Design and execute experiments bridging chemistry and molecular biology.
• Analyze experimental data, generate detailed reports, and provide actionable insights to guide further development.
• Apply statistical methods and process evaluation tools to ensure workflow quality and performance.
• Prepare and maintain comprehensive documentation of protocols, SOPs, and results.
• Contribute to process innovation and support technology transfer as workflows mature.

What you need

Required:

• Degree in organic chemistry, surface chemistry, bioengineering or equivalent field. Advanced degree preferred.
• 6+ years (PhD), 8+ years (MS), 10+ years (B.S.) of industry or equivalent experience in assay or reagent development.
• Demonstrated proficiency in surface and morphological characterization (AFM, SEM/TEM, XPS, contact angle, DLS, zeta potential).
• Expertise in surface and solid-phase chemistry, including surface modification, functional group coupling (and quantitation), and polymer or nanoparticle surface engineering.
• Demonstrated proficiency in analytical characterization, including LC–MS, HPLC, FTIR, UV–Vis, fluorescence spectroscopy, and elemental analysis.
• Hands-on experience with bioconjugation chemistry, such as coupling of proteins, peptides, small molecules, or oligonucleotides via covalent or affinity-based linkers.
• Excellent problem-solving skills and attention to detail.
• Excellent written and verbal communication skills, with the ability to work seamlessly with colleagues from diverse scientific and technical backgrounds.
• Ability to thrive in a fast-paced environment with evolving priorities.

Nice to have:

• Familiarity with microfluidics and flow cells.
• Experience in photochemistry and photocatalysis.
• Experience with automation platforms for liquid handling (e.g. Hamilton, ThermoFisher, Agilent).
• Familiarity with statistical methods or computational tools for process/data analysis.
• Experience supporting technology transfer into production environments.

We’re looking for teammates with:

• Excellent interpersonal skills – capable of building strong relationships and communicating effectively with stakeholders at all levels.
• High emotional and analytical intelligence – able to navigate complex team dynamics, partnerships, and challenges with creativity and logic.
• Resourceful adaptability – operates with urgency, remains flexible in evolving environments, and thrives in ambiguity.
• Collaborative spirit – enjoys working across disciplines and explaining complex concepts to diverse audiences.

What you can expect from this role

Work environment:

• Collaborative culture where your ideas and expertise are valued
• Direct impact on product development and company direction

Professional growth:

• Learn from a diverse team of world-class scientists and engineers
• Contribute to first-of-their kind technologies, high-impact publications, and patents

Compensation

Estimated Base Salary $120,000 - $183,000

This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.

Benefits and Perks:

• Employee Stock Option Plan
• 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
• Employer Retirement Contributions to 401(k)
• Generous Paid Time Off
• Paid Maternity and Paternity Leave
• Health & Wellbeing Program
• Office Snacks and Beverages
• Regular Team Bonding Activities

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.