Senior Director, Brand Lead - Varegacestat

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs). Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors; IM-1021, a ROR1-targeted ADC which is currently in a Phase 1 trial; and IM-3050, a FAP-targeted radioligand, which recently received IND clearance. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors.

Position Overview

The Senior Director, Brand Lead for Varegacestat offers an exceptional opportunity for an experienced, strategic, and scientifically grounded leader with a proven record in launching novel oncology therapies. Varegacestat is a potential best in class agent under investigation for desmoid tumors. This role will lead the US launch efforts across both healthcare provider (HCP) and patient channels and drive overall cross-functional launch readiness. The position requires advanced expertise in pharmacology and clinical therapeutics to drive HCP education, shape the brand’s scientific narrative, and ensure effective communication of Varegacestat’s clinical value. As a key member of the leadership team, this individual will define and execute the marketing strategy for the brand, playing a pivotal role in advancing Immunome’s oncology portfolio and setting the foundation for long-term growth.

Key Responsibilities

Lead Varegacestat Go-to-Market Strategy

• Lead the development of brand strategy and scientific narrative grounded in clinical differentiation and pharmacologic profile from the RINGSIDE study (the pivotal registration phase III trial).
• Shape brand positioning by intergrating clinical data, mechanistic insights, and competitive intelligence to highlight therapeutic value and differentiation.
• Design and implement engagement strategies with key academic and community institutions, key opinion leaders, and key healthcare providers to ensure scientific alignment and clinical awareness.
• Lead the creation of annual brand strategic and tactical plan.

Lead HCP and Patient Promotional Education Efforts to Drive Best-in-Class Launch

• Lead the design and execution of medical and promotional education for HCP audiences that effectively communicate Varegacestat’s clinical profile (i.e. mechanism of action, dosing, efficacy and safety profile).
• Manage marketing mix investments across all commercial verticals, ensuring data-driven decisions that reinforce awareness and scientific credibility.
• Enhance Immunome’s visibility and reputation by amplifying presence at major oncology congresses.
• Collaborate with medical affairs, clinical development, legal and regulatory teams to ensure all communications to healthcare professionals and patients are scientifically accurate, therapeutically appropriate, and upholding FDA OPDP regulations.

Drive an Agile and High Performing Brand Team

• Lead the selection and management of creative and media agency partners to support timely and best in class launch.
• Support the development of efficient commercial MLR process and Veeva Valut execution.
• Represent the commercial function in cross-functional governances to drive program-level decisions.
• Partner with finance and commercial analytics functions to ensure plans maximize brand value and provide regular updates to senior leaders on promotional strategies, tactics, and overall brand performance.
• Support executive leadership through strategic insights, ad hoc analyses, and data-driven recommendations to maximize brand and organizational impact.

Qualifications

• A minimum of 10 years of experience in US and Global marketing in the pharmaceutical or biotech industry with demonstrated expertise in pharmaceutical brand strategy or lifecycle management; Oncology experience is a must.
• Advanced medical related degree preferred (MD, DO, PharmD). MBA preferred.
• Oncology sales experience preferred.
• Technical and functional expertise in HCP channel marketing across personal, digital, peer-to-peer and omnichannel.
• Strong knowledge of U.S. FDA and other market experience (e.g. Canada PAAB’s promotional regulations) and medical–legal-regulatory review processes.

Knowledge and Skills

• Expertise in pharmacology, clinical data interpretation, and therapeutic communication to healthcare professionals.
• Expertise in executing a successful US Oncology drug launch focusing on healthcare provider and patient education.
• Proven track record of identifying customer needs and extracting and translating key insights into meaningful strategies and tactics.
• Demonstrated success developing, executing and measuring complex marketing programs and championing innovative solutions.
• Hands on experience leading commercial assessments and investment decisions.
• Demonstrated cross functional teamwork capabilities.
• Excellent verbal and written communication skills for a wide range of audiences.
• Strong cross-functional leadership skills and ability to influence without authority.
• Excellent strategic and analytical thinking abilities.
• Agile and adaptable with a growth mindset.

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).