Sr. Scientist, Analytical Development and QC, Biologics

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugate therapies. Our pipeline includes varegacestat, a late-clinical stage GSI; IM-1021, a clinical-stage ROR1 ADC; and IM-3050, a FAP-targeted radiotherapy that recently received IND clearance. We are also advancing a broad portfolio of early stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

Immunome is seeking an experienced Senior Scientist, Analytical Development & QC to support its Antibody Drug Conjugate (ADC) portfolio. This role will be responsible for leading physicochemical analytical method development in collaboration with Contract Development and Testing Laboratories (CDMOs and CTLs), while also supporting the buildout of internal CMC analytical capabilities.

The successful candidate will bring strong hands-on expertise in ADC analytical method development and product characterization, with particular depth in Liquid Chromatography (LC), Capillary Electrophoresis (CE, including icIEF), and Mass Spectrometry–based techniques. Experience managing external analytical testing activities, supporting technology transfer, and contributing to regulatory submissions is highly valued.

Responsibilities

• Develop and execute physicochemical analytical methods for ADC characterization, release, and stability testing using LC, CE, icIEF, and MS technologies.
• Implement CMC analytical method development activities within Immunome laboratories in alignment with phase-appropriate requirements.
• Collaborate with Contract Testing Laboratories (CTLs) to develop, qualify, and validate robust analytical testing methodologies.
• Serve as Analytical Lead for assigned pipeline programs, providing scientific guidance on data interpretation and analytical strategy.
• Contribute to preparation of analytical sections of regulatory submissions and technical reports.
• Draft and review method protocols, development reports, and method transfer packages to support GMP activities.
• Maintain awareness of emerging analytical technologies and evolving regulatory expectations, integrating relevant innovations into Immunome’s analytical and QC strategy.
• Collaborate cross-functionally with Discovery, Process Chemistry, Formulation Development, and Quality teams to ensure analytical approaches align with broader program needs.

Qualifications

• Bachelor’s, Master’s, or PhD in Analytical Chemistry, Biochemistry, or a related scientific discipline.
• A minimum of 5 years of industry experience supporting CMC analytical method development with direct ADC experience.
• Demonstrated experience in analytical method development, qualification/validation, and QC support for biologics or ADCs.
• Experience managing external CDMO/CTL analytical activities, including oversight of timelines, data quality, and deliverables.
• Hands-on experience supporting analytical method transfer to external laboratories and/or GMP environments.
• Strong working knowledge of analytical separation principles for biologics and complex conjugated modalities.

Knowledge and Skills

• Proven experience in phase-appropriate analytical method development for ADC product characterization, release, and stability testing.
• Strong understanding of ADC product attributes, including conjugation chemistry, linker-payload properties, and DAR-related quality considerations.
• Hands-on expertise with advanced analytical platforms, including capillary electrophoresis, HPLC/UPLC, and mass spectrometry.
• Ability to interpret complex analytical data and translate results into actionable development insights.
• Strong communication skills and ability to collaborate effectively across cross-functional teams.
• Demonstrated ability to manage multiple priorities, troubleshoot complex technical challenges, and operate effectively in a dynamic, fast-paced environment.

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).