Associate Director / Director, Total Rewards

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugate therapies. Our pipeline includes varegacestat, a late-clinical stage GSI; IM-1021, a clinical-stage ROR1 ADC; and IM-3050, a FAP-targeted radiotherapy that recently received IND clearance. We are also advancing a broad portfolio of early stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

The Associate Director / Director, Total Rewards will strengthen engagement and retention by building a competitive, scalable, and employee-centered total rewards. This role will lead the design and administration of compensation practices, benefits, leave programs, 401(k), equity planning, and rewards & recognition ensuring our offerings attract, motivate, and retain top talent while remaining compliant, cost-effective, and aligned to our culture.  

Responsibilities

Engagement and Retention 

• Develop and execute a total rewards strategy that supports talent attraction, engagement, and retention.  

• Partner with other functions of HR and business leaders to ensure rewards programs reinforce performance, internal equity, and our culture.  

• Translate company growth and workforce needs into scalable and fiscally responsible rewards programs.   

  

Compensation Programs 

• Lead the development, implementation, and ongoing management of compensation plans, including salary structures, incentive programs, market pricing, pay equity analysis, and compliance oversight.  

• Support equity planning (new hire grants, promotions, refresh cycles, and annual planning) in coordination with Finance, Legal, and the equity administration partner.  

• Prepare for and support the annual compensation cycle (merit, promotion, bonus planning as applicable): tools, timelines, manager guidance, calibration support, and reporting.  

• Assist Chief Financial Officer by researching trends, gathering data and preparing compensation information to be reviewed by executive team, compensation committee, and board of directors.  

  

Benefits Administration  

• Oversee day-to-day benefits administration including medical, dental, vision, life/AD&D, disability, FSA, and related programs.  

• Own leave administration processes (e.g., FMLA, state leaves, disability coordination), ensuring an excellent employee experience and compliant practices.  

• Manage 401(k) administration: vendor partnership, annual testing support, audits as needed, enrollment and education initiatives.  

• Lead annual benefits renewal: plan design evaluation, cost modeling, vendor negotiations, open enrollment project management, and employee communications.  

• Ensure compliance with applicable regulations (e.g., ERISA, COBRA, HIPAA, ACA) in partnership with legal/benefits vendors and internal stakeholders.  

  

Rewards & Recognition  

• Own and improve recognition programs that reinforce values and performance (spot awards, peer recognition, and milestone/service awards).  

• Partner with people leaders to ensure recognition is timely, inclusive, and consistently applied across teams.  

  

Stakeholder Partnership & Influence  

• Serve as a strategic advisor to leaders on total rewards decisions, tradeoffs, and communications.  

• Collaborate closely with HRBPs, Talent Acquisition team, Payroll, Finance, Legal, and People Operations to ensure seamless program delivery.  

• Lead vendor relationships (brokers, carriers, leave administrator, 401(k) provider, compensation survey partners, recognition platform).  

  

Measurement & Continuous Improvement  

• Monitor costs, utilization, participation, and employee feedback to refine offerings and improve experience.  

• Create scalable documentation, SOPs, and governance for all total rewards programs.  

  

Qualifications

• Bachelor’s Degree required. 

• A minimum of 8+ years of progressive experience in Total Rewards, Compensation, Benefits, or HR, including program ownership in a scaling organization. 

• Biotech/life science industry experience is strongly preferred.  

  

Knowledge and Skills

• Hands-on experience with benefits administration (health plans, leave administration, 401(k)) and vendor management.  

• Strong compensation experience including benchmarking roles, creating job architecture/leveling frameworks administering annual compensation cycles, and supporting sales incentive programs.   

• Demonstrated experience with equity administration platforms and stock plan basics.  

• Strong analytical skills (modeling, reporting, and presenting insights) and ability to translate data into clear recommendations.   

• Strong stakeholder influence and experience partnering cross-functionally with Finance, Legal, Payroll, and senior leaders.  

• Excellent facilitation, program design, and communication skills.  

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).