Computational Protein Engineer (Biologics), London

Computational Protein Engineer (Biologics), London

We are here to advance human health, by reimagining drug discovery with the power and pace of artificial intelligence.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured by better and faster drug discovery. 

Our values exist in service of that future. We think they’ll help us bring it closer, too. 

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you. 

About Iso

Isomorphic Labs (IsoLabs) was founded in 2021 and is led by Sir Demis Hassabis. Our aim is to usher in a new era of biomedical breakthroughs and find cures for some of humanity’s devastating diseases.

Our foundations are built on the success of Google DeepMind’s AlphaFold, but we didn’t stop there! We are continuing to develop and implement state-of-the-art technologies as we move towards our goal of dramatically accelerating and improving the process of designing and bringing new medicines to patients.

We have built a world-leading drug design engine comprising foundational AI models that are capable of working across multiple therapeutic areas and drug modalities. The company is continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

 

Your impact 

As part of the ongoing expansion of our Drug Design and Medical Research function, we are looking to recruit a Computational Protein Engineer. You will collaborate with world leading teams to deliver scientific expertise and strategic direction to drive both improvements in the Platform and apply this to real drug design problems. 

If you are a skilled and ambitious scientist looking to take the next step in your career, joining the Isomorphic Labs now will lift you out of your comfort zone and provide you with an amazing opportunity for personal growth and development. The position requires an active, individual contributor with hands-on responsibilities, not a people manager.

 

What you will do 

• Apply your knowledge and track record of modern drug design principles to provide effective tools using our internal state-of-the-art ML models and Platform to execute Drug Design programs
• Collaborate both internally and with third party organisations interacting within multidisciplinary teams to support data-driven delivery of high quality scientific solutions to complex technical problems
• Mentoring and supporting other members of the growing team in their development
• Prepare detailed scientific proposals and reports to support new and ongoing programs
• Embrace and champion our culture of inclusion and continuous professional development

Skills and qualifications 

Essential:

• Extensive industry experience in a pharma/biotech environment
• Experience working in multidisciplinary large molecule drug discovery teams
• Proficient programming skills with a strong emphasis in Python
• PhD in computational chemistry, structural biology, biochemistry or related field, or alternatively a Master’s degree with equivalent industry experience
• Experience of working on biologics projects, including antibody therapeutics
• In depth knowledge of protein structure, gained through experience with protein 3D models, protein function analysis and identification of key interactions
• Experience preparing datasets, benchmarking different types of tooling, and working with structure-based metrics
• Comfortable learning new ways of working and can work in fast changing environments

Nice to have:

• Experience using generative-design methods (preferably ML-based) for biologics
• Experience of leading or co-leading drug discovery program teams
• Experience of working in immunology and oncology therapeutic areas preferably in the context of therapeutic biologics discovery
• Has worked in an industry partnership/collaboration
• Experience working with antibody sequencing data
• Experience of working with complex biologics modalities, such as antibody-drug conjugates (ADC’s) or multi-specifics and working knowledge of medicinal chemistry principles for peptides
• Understanding and application of molecular dynamics methodologies to study protein dynamics and interactions

Culture and values

We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it. 

Thoughtful
Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.

Brave
Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less.

Determined
Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we.

Together
Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere.

Creating an extraordinary company

We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.

Hybrid working

It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call.

Please note that when you submit an application, your data will be processed in line with our privacy policy.

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